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Analysis of antitumor immunity induced by vaccinia virus with in vivo imaging

Research Project

Project/Area Number 25462254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKyoto University

Principal Investigator

Arakawa Yoshiki  京都大学, 医学(系)研究科(研究院), 助教 (20378649)

Co-Investigator(Kenkyū-buntansha) Dean Thumkeo  京都大学, 医学研究科, 助教 (40372594)
Co-Investigator(Renkei-kenkyūsha) Matsuda Michiyuki  京都大学, 医学研究科, 教授 (10199812)
Research Collaborator Murata Daiki  
Fujimoto Ko-ichi  
Yokogawa Ryuta  
Terada Yukinori  
Fukui Nobuyuki  
Liu Bin  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords悪性脳腫瘍 / ワクシニアウイルス / 生体イメージング / 腫瘍免疫 / 免疫誘導 / ウイルス治療 / 悪性グリオーマ
Outline of Final Research Achievements

The aim of the project is to analyze oncolytic bioresponse induced by vaccinia virus, and to develop the new oncolytic therapy. Our previous results indicate that the antitumor immunity activated by vaccinia virus is effective for malignant brain tumors. In brain tumor models, the induction of antitumor immune competent cells was identified by immunohistochemical staining and flow cytometry, although it was not sufficient for long-term tumor control. As Flt3L is known to be a strong stimulator of antitumor immune system, Flt3L-expressing vaccinia virus has been developed. The in vivo analyzing system of antitumor immunity has been prepared to evaluate efficacy of Flt3L-expressing vaccinia virus. The status of antitumor immunity in medulloblastoma was analyzed. We confirmed that high PD-L1 expression and low CD8+ lymphocyte infiltration was associated with worse survival in patients with medulloblastoma.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2013

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Factors Predicting the Effects of Hybrid Assistive Limb Robot Suit during the Acute Phase of Central Nervous System Injury2016

    • Author(s)
      1.Hideo Chihara, Yasushi Takagi, Kazunari Nishino, Kazumichi Yoshida, Yoshiki Arakawa, Takayuki Kikuchi, Yohei Takenobu, Susumu Miyamoto
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 56 Issue: 1 Pages: 33-37

    • DOI

      10.2176/nmc.oa.2015-0178

    • NAID

      130005119820

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High mobility group A1 expression shows negative correlation with recurrence time in patients with glioblastoma multiforme.2015

    • Author(s)
      4.Bin Liu, Bo Pang, Huajie Liu, Yoshiki Arakawa, Rui Zhang, Bin Feng, Peng Zhong, Daiki Murata, Haitao Fan, Tao Xin, Guangyu Zhao, Wei Liu, Hua Guo, Liming Luan, Shangchen Xu, Susumu Miyamoto, Qi Pang.
    • Journal Title

      Pathology - Research and Practice

      Volume: 211 Issue: 8 Pages: 596-600

    • DOI

      10.1016/j.prp.2015.05.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] rimary central nervous system lymphoma: is absence of intratumoral hemorrhage a characteristic finding on MRI?2015

    • Author(s)
      5.Akihiko Sakata, Tomohisa Okada, Akira Yamamoto, Mitsunori Kanagaki, Yasutaka Fushimi, Toshiki Dodo, Yoshiki Arakawa, Jun C Takahashi, Susumu Miyamoto, Kaori Togashi.
    • Journal Title

      Radiology and Oncology

      Volume: 49 Issue: 2 Pages: 128-134

    • DOI

      10.1515/raon-2015-0007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Grading glial tumors with amide proton transfer MR imaging: different analytical approaches.2015

    • Author(s)
      Sakata, A., T. Okada, A. Yamamoto, M. Kanagaki, Y. Fushimi, T.Okada, T. Dodo, Y. Arakawa, B. Schmitt, S. Miyamoto, K.
    • Journal Title

      J Neurooncol

      Volume: 122 Issue: 2 Pages: 339-48

    • DOI

      10.1007/s11060-014-1715-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of salvage stereotactic radiotherapy for recurrent glioma: impact of tumor morphology and method of target delineation on local control.2013

    • Author(s)
      Kengo Ogura, Takashi Mizowaki, Yoshiki Arakawa, Katsuyuki Sakanaka, Susumu Miyamoto, Masahiro Hiraoka..
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 2(6): Issue: 6 Pages: 942-949

    • DOI

      10.1002/cam4.154

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Retrospective Analysis of Bevacizumab in Combination With Ifosfamide, Carboplatin, and Etoposide in Patients With Second Recurrence of Glioblastoma2013

    • Author(s)
      oshiki Arakawa, Takashi Mizowaki, Daiki Murata, Koichi Fujimoto, Takayuki Kikuchi, Takeharu Kunieda, Jun C. Takahashi, Yasushi Takagi, Susumu Miyamoto.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 53 Issue: 11 Pages: 779-785

    • DOI

      10.2176/nmc.oa2013-0211

    • NAID

      10031196789

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component.2013

    • Author(s)
      Takeuchi Y, Arakawa Y, Mikami Y, Matsumoto R, Miyamoto S.
    • Journal Title

      Brain Tumor Pathol

      Volume: 31 Issue: 2 Pages: 144-8

    • DOI

      10.1007/s10014-013-0155-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution.2013

    • Author(s)
      K Ogura, T Mizowaki, Y Arakawa, M Ogura, K Sakanaka, S Miyamoto2 and M Hiraoka.
    • Journal Title

      Radiation Oncology

      Volume: 8:97 Issue: 1 Pages: 1-9

    • DOI

      10.1186/1748-717x-8-97

    • NAID

      120005323035

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Organizing intracerebral hematoma mimicking a recurrent brain tumor on FDG-PET.2013

    • Author(s)
      Satoshi Nakajima, Tomohisa Okada, Yoshiki Arakawa, Yoshiki Mikami, Kaori Togashi
    • Journal Title

      Clinical Nuclear Medicine,

      Volume: 38(11) Issue: 11 Pages: e411-e413

    • DOI

      10.1097/rlu.0b013e31827085ce

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 膠芽腫初回再発に対する放射線療法併用BICE療法2015

    • Author(s)
      荒川芳輝、峰晴陽平、丹治正大、青木友和、上羽哲也、北条雅人、岩崎孝一、高橋淳B、國枝武治、高木康志、宮本享
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Retrospective review of glioblastoma patients treated with bevacizumab-containing and non-bevacizumab-containing regimens in a single institution2015

    • Author(s)
      Yoshiki Arakawa, Takashi Mizowaki, Masahiro Tanji, Yohei Mineharu, Kengo Ogura, Megumi Uto, Takeharu Kunieda, Yasushi Takagi, Susumu Miyamoto
    • Organizer
      The 20th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
    • Place of Presentation
      San Antonio, Texas
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Endoscopic port surgeryの適応と限界2015

    • Author(s)
      荒川芳輝 姜裕 丹治正大 峰晴陽平 國枝武治 高木康志 宮本享
    • Organizer
      日本脳神経外科学会第74回学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Bevacizumab, ifosfamide, carboplatin, and etoposide (BICE) concomitant with radiotherapy in patients with first recurrence of glioblastoma after temozolomide treatment.2015

    • Author(s)
      Yoshiki Arakawa, Takashi Mizowaki, Yohei Mineharu, Masaharu Tanji, Kengo Ogura, Megumi Uto, Yasushi Takagi, Susumu Miyamoto
    • Organizer
      the 12th Meeting of the Asian Society for Neuro-Oncology
    • Place of Presentation
      Manila, Philippines
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中間型松果体実質腫瘍におけるソマトスタチン受容体発現の検討2015

    • Author(s)
      2015年5月29日(金)・30日(土)
    • Organizer
      第33回日本脳腫瘍病理学会学術集会
    • Place of Presentation
      高松
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳室近傍腫瘍に対する内視鏡単独手術の適応と限界2013

    • Author(s)
      荒川芳輝
    • Organizer
      第18回日本脳腫瘍の外科学会
    • Place of Presentation
      大津
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳室・脳室近傍腫瘍に対する内視鏡単独腫瘍摘出術2013

    • Author(s)
      荒川芳輝
    • Organizer
      第20回日本神経内視鏡学会
    • Place of Presentation
      山梨
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳室・脳室近傍腫瘍に対する内視鏡単独腫瘍摘出術2013

    • Author(s)
      荒川芳輝
    • Organizer
      日本脳神経外科学会・第72回学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性グリオーマに対するウイルス療法に伴う腫瘍免疫機構の解析2013

    • Author(s)
      村田大樹、荒川芳輝、藤本浩一、山口真、平田英周、宮本 享
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report
  • [Presentation] 再々発膠芽腫に対するbevacizumab併用ICE療法の治療経験と多施設共同試験による検証の提案2013

    • Author(s)
      荒川芳輝、青木友和、上羽哲也、北条雅人、岩崎孝一、丹治正大、國枝武治、高橋淳B、高橋淳C、高木康志、宮本享
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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