Imaging of malignant brain tumor after treatment with VEGF inhibitor
| Project/Area Number |
25462262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kurisu Kaoru 広島大学, 医歯薬保健学研究院, 教授 (70201473)
Sugiyama Kazuhiko 広島大学, 病院, 教授 (30243554)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | glioblastoma / malignant lymphoma / DWI / 1HMRS / VEGF / cavernous angioma / cranial irradiation / bevacizumab / glioma / FLAIR / RANO |
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| Outline of Final Research Achievements |
We investigated the risk factors for brain apoplexy after VEGF treatment. Our study indicated that hemorrhagic apoplexy developed within 3 months、while thromboembolic apoplexy develop 6 months after VEGF treatment, and related to risk factor of brain infarction including hypertension. Our study revealed that the relationship between tumor location and the lesion of DWI high intensity was important for differentiation between true- and pseudo-response after bevacizumab treatment. Large lipid peaks on 1H-MRS images of tumors without central necrosis were characteristic of malignant lymphomas. Conversely, small or absent lipid peaks in intraaxial tumors without central necrosis were strongly suggestive of glioma. Patients who underwent radiation therapy with primitive neuroectodermal tumors or pineoblastoma developed Zabramski type 1 and 2 CVA significantly earlier than did medulloblastoma patients.
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Transient spontaneous regression of brainstem glioblastoma: case report and review of the literature.2016
Author(s)
Yamasaki F, Takayasu T, Nosaka R, Haratake D, Arihiro K, Ueno H, Shimomura R, Akiyama Y, Sugiyama K, Matsumoto M, Kurisu K.
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Journal Title
Journal of Neurosurgical Sciences
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] A Multicenter Phase I/II Study of the BCNU Implant (Gliadel® Wafer) for Japanese Patients with Malignant Gliomas.2013
Author(s)
Aoki T, Nishikawa R, Sugiyama K, Nonoguchi N, Kawabata N, Mishima K, Adachi JI, Kurisu K, Yamasaki F, Tominaga T, Kumabe T, Ueki K, Higuchi F, Yamamoto T, Ishikawa E, Takeshima H, Yamashita S, Arita K, Hirano H, Yamada S, Matsutani M.
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Journal Title
Neurol Med Chir (Tokyo)
Volume: 54
Pages: 290-301
NAID
Related Report
Peer Reviewed
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