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Verification of ventricular enlargement mechanism in idiopathic normal pressure hydrocephalus using with hypertensive rat

Research Project

Project/Area Number 25462263
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionYamaguchi University

Principal Investigator

NOMURA Sadahiro  山口大学, 医学(系)研究科(研究院), 准教授 (20343296)

Co-Investigator(Kenkyū-buntansha) SHIRAO Satoshi  山口大学, 大学院医学系研究科, 助教 (70448281)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordshydrocephalus / risk factor / hypertension / rat / 正常圧水頭症 / 高血圧
Outline of Final Research Achievements

Objective: In hydrocephalus state, cerebrospinal fluid (CSF) does not enlarge subarachnoid space but cerebral ventricles. In the present study, the hypothesis that pulsation of intraventricular arteries expands the ventricles was investigated. Methods: Spontaneous hypertensive rat (SHR) and normotensive Wistar rat were subjected for the study. Kaolin was injected into the basal cisterns to develop hydrocephalus. The ventricular size was measured two weeks later. Results: Ventricle width / brain width of SHR is 48 ± 12%, which was significantly larger than 39 ± 12% of the Wistar rat (p = 0.04). Conclusion: Hypertensive rat indicated ventricular enlargement in larger extent than normotensive rat. Hypertension could be one of the reason to enlarge ventricular size.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] くも膜下出血後の外水頭症の特徴2015

    • Author(s)
      野村貞宏、石原秀行、小泉博靖、末廣栄一、白尾敏之、五島久陽、奥高行、貞廣浩和、鈴木倫保
    • Journal Title

      第15回日本正常圧水頭症学会記録集

      Volume: 15 Pages: 15-15

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 臨床各科差分解説:Dandy-Walker complexの分類とBlake’s pouch cystに対する脳室穿破術2015

    • Author(s)
      野村貞宏、鈴木倫保
    • Journal Title

      日本医事新報

      Volume: 4782 Pages: 54-54

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Reliability of laser speckle flow imaging for intraoperative monitoring of cerebral blood flow during cerebrovascular surgery: Comparison with cerebral blood flow measurement by single photon emission computed tomography2014

    • Author(s)
      Nomura S, Inoue T, Ishihara H, Koizumi H, Suehiro E, Oka F, Suzuki M.
    • Journal Title

      World Neurosurgery

      Volume: 81 Issue: 6 Pages: 1-5

    • DOI

      10.1016/j.wneu.2013.09.012

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of persistent hydrocephalus cases after endoscopic third ventriculostomy2013

    • Author(s)
      Sadahiro Nomura, Makoto Ideguchi, Hirokazu Sadahiro, Hisaharu Goto, Michiyasu Suzuki
    • Journal Title

      Journal of Hydrocephalus

      Volume: 5 Pages: 26-30

    • NAID

      40020916358

    • Related Report
      2013 Research-status Report
  • [Journal Article] 特発性正常圧水頭症におけるシャント術後の脳血液量増加2013

    • Author(s)
      野村貞宏、丸田雄一、稲村彰紀、五島久陽、鈴木倫保
    • Journal Title

      日本正常圧水頭症学会記録集

      Volume: 14 Pages: 41-41

    • Related Report
      2013 Research-status Report
  • [Presentation] 局所麻酔下の脳室腹腔シャント延長術2015

    • Author(s)
      野村貞宏、秋村龍夫、西本拓真、鈴木倫保
    • Organizer
      第33回日本こども病院神経外科医会
    • Place of Presentation
      新潟大学講堂 (新潟県新潟市)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] RI脳槽造影による髄液鼻漏・耳漏の判定2015

    • Author(s)
      野村貞宏,末廣栄一,井本浩哉,五島久陽、篠山瑞也,國次一郎,鈴木倫保
    • Organizer
      第8回日本水頭症髄液学会
    • Place of Presentation
      順天堂大学講堂 (東京都文京区)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] RI脳槽造影による髄液鼻漏の判定2015

    • Author(s)
      野村貞宏,末廣栄一,井本浩哉,五島久陽、篠山瑞也,國次一郎,鈴木倫保
    • Organizer
      第74回日本脳神経外科学会学術総会
    • Place of Presentation
      ロイトン札幌 (北海道札幌市)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chronological and Topographical Expression of the Benzodiazepine Receptor in the Developing Brain2013

    • Author(s)
      Sadahiro Nomura, Hiroyasu Koizumi, Eiichi Suehiro, Michiyasu Suzuki, Hidekatsu Kiya
    • Organizer
      The 15th WFNS World Congress of Neurosurgery
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 第三脳室底開窓術不成功例の検討 -脳コンプライアンスと開窓孔の抵抗に関する考察-2013

    • Author(s)
      野村貞宏、出口誠、貞廣浩和、五島久陽、鈴木倫保
    • Organizer
      第20回日本神経内視鏡学会
    • Place of Presentation
      甲府市、甲府富士屋ホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] シャント手術における整容:臍輪アプローチによる腹腔カテーテル挿入法2013

    • Author(s)
      野村 貞宏、稲村 彰紀、杉本 至健、藤山 雄一、山根亜希子、鈴木 倫保
    • Organizer
      第6回日本水頭症脳脊髄液学会
    • Place of Presentation
      東京都、東京医科大学病院臨床講堂
    • Related Report
      2013 Research-status Report
  • [Presentation] くも膜下出血後の髄液循環障害と水頭症

    • Author(s)
      野村貞宏
    • Organizer
      2013小児及びsNPHのシャント治療症例検討会in福岡
    • Place of Presentation
      福岡市、博多駅前ビジネスセンター
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 体内埋め込み医療材料の開発とその理想的な性能・デザインの要件2013

    • Author(s)
      野村貞宏、鈴木倫保
    • Total Pages
      440
    • Publisher
      技術情報協会
    • Related Report
      2013 Research-status Report
  • [Book] 小児脳神経外科診療ガイドブック2013

    • Author(s)
      野村貞宏
    • Total Pages
      384
    • Publisher
      メジカルビュー社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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