| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Objective: In hydrocephalus state, cerebrospinal fluid (CSF) does not enlarge subarachnoid space but cerebral ventricles. In the present study, the hypothesis that pulsation of intraventricular arteries expands the ventricles was investigated. Methods: Spontaneous hypertensive rat (SHR) and normotensive Wistar rat were subjected for the study. Kaolin was injected into the basal cisterns to develop hydrocephalus. The ventricular size was measured two weeks later. Results: Ventricle width / brain width of SHR is 48 ± 12%, which was significantly larger than 39 ± 12% of the Wistar rat (p = 0.04). Conclusion: Hypertensive rat indicated ventricular enlargement in larger extent than normotensive rat. Hypertension could be one of the reason to enlarge ventricular size.
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