| Project/Area Number |
25462271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
倉津 純一 熊本大学, 大学院生命科学研究部(医), 教授 (20145296)
篠島 直樹 熊本大学, 医学部附属病院, 寄附講座教員 (50648269)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 悪性神経膠腫 / 電場変容 / パルス電流 / ヌードマウス / 悪性神経膠腫瘍 |
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| Outline of Final Research Achievements |
Modulation of electric field is a new treatment modality of malignant glioma. U87 glioma cells were injected beneath the skin of nude mouse (ICR-nu). The tumor grew to 2 cm in diameter within 40 days. The stimulation electrode was inserted into the tumor, then electric stimulation was applied for 30 minutes. Two days after the electric stimulation, the tumor was removed and prepared for histological examinations. H-E, MIB-1, and TUNEL staining revealed the morphological changes of the tumor cells and alteration of inflamatory cells. Based on the result of this study, we elaborate a plan by clinical application to malignant glioma treatment located in the brainstem in the future.
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