| Project/Area Number |
25462273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
Nakamura Hideo 熊本大学, 医学部附属病院, 講師 (30359963)
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| Co-Investigator(Kenkyū-buntansha) |
倉津 純一 熊本大学, 大学院生命科学研究部(医), 教授 (20145296)
秀 拓一郎 熊本大学, 医学部附属病院, 診療講師 (40421820)
荒木 令江 熊本大学, 大学院生命科学研究部(医), 准教授 (80253722)
牧野 敬史 熊本大学, 医学部附属病院, 講師 (90381011)
黒田 順一郎 熊本大学, 大学院生命科学研究部(医), 助教 (90536731)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMIZAWA Kazuhito 熊本大学, 生命科学研究部, 教授 (40274287)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Glioma Stem cell / penetrating peptuide / autophagy / micelle / 膜透過性ペプチド / 悪性神経膠腫 / オートファジー / 薬剤内包ミセル / グリオーマ幹細胞 / p53 / アポトーシス / 動物実験モデル / 細胞膜透過性ペプチド / 腫瘍特異的細胞死 / ｐ53 C末端ペプチド / オートファジー細胞死 |
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| Outline of Final Research Achievements |
Glioblastoma is resistant to chemotherapy and radiation therapy. Therefore, to overcome this resistancy, we planned the experiment using cell-penetrating peptide. This peptide were wrapped by a Micelle to be delivered the tumor cells in vivo. Glioma Stem Cell (GSC) were established from surgical samples and as soon as possible they were injected to nude mice. Autophagy was observed by several experiments using this cell-penetrating peptide. We need more animal experiments to testify these phenomenon.
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