• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Towards personalized treatment of gliomas -specifically to explore the indication of neoadjuvant chemotherapy for gliomas-

Research Project

Project/Area Number 25462278
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKeio University

Principal Investigator

Yoshida Kazunari  慶應義塾大学, 医学部, 教授 (70166940)

Co-Investigator(Kenkyū-buntansha) SASAKI Hikaru  慶應義塾大学, 医学部, 講師 (70245512)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経膠腫 / 1p19q / 共欠失 / neoadjuvant / chemotherapy / 術前化学療法 / Glioma / neoadjuvant chemotherapy / 個別化治療 / 脳腫瘍 / 1p/19q
Outline of Final Research Achievements

Codeletion of chromosomes 1p and 19q is predictive for favorable prognosis in the patients with oligodendroglial tumors. We suggested that gliomas with 1p19q codeletion with some or more “astrocytic” features also had comparable biological and prognostic characteristics to those with oligodendroglial features (Oncotarget).
We showed that upfront chemotherapy for molecularly defined chemosensitive gliomas with the intension of second-look resection for initial incomplete resections might compare favorably with chemotherapy only, and suggested the usefulness of neoadjuvant strategy for the first time (J Neurooncol). We found that combination of surface localization and calcification strongly predicted 1p19q codeletion, and these radiological evaluation would help to segregate the candidates to be treated with neoadjuvant strategy (Neurosurg Rev).

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (38 results)

All 2016 2015 2014 2013 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results,  Open Access: 4 results) Presentation (21 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Molecular Classification and Personalized Treatment of Gliomas2016

    • Author(s)
      佐々木光、吉田一成
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 44 Issue: 3 Pages: 185-201

    • DOI

      10.11477/mf.1436203256

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatal hemorrhage in a patient with advanced soft tissue sarcoma following radiation and pazopanib treatment: A case report2016

    • Author(s)
      Kawasaki K, Hamamoto Y, Fukada J, Adachi M, Sasaki H, Takaishi H, Yoshida K, Kanai T
    • Journal Title

      Oncology letters

      Volume: 11(4) Issue: 4 Pages: 2408-2410

    • DOI

      10.3892/ol.2016.4246

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic characterization of skull base chondrosarcomas2015

    • Author(s)
      Kanamori H, Kitamura Y, Kimura T, Yoshida K, Sasaki H
    • Journal Title

      Journal of Neurosurgery

      Volume: 123(4) Issue: 4 Pages: 1036-41

    • DOI

      10.3171/2014.12.jns142059

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort2015

    • Author(s)
      Hayashi S, Sasaki H, Kimura T, Abe T, Nakamura T, Kitamura Y, Miwa T, Kameyama K, Hirose Y, Yoshida K
    • Journal Title

      Oncotarget

      Volume: 6(18) Issue: 18 Pages: 15871-81

    • DOI

      10.18632/oncotarget.3869

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Upfront chemotherapy and subsequent resection for molecularly defined gliomas2015

    • Author(s)
      Sasaki H, Hirose Y, Yazaki T, Kitamura Y, Katayama M, Kimura T, Fujiwara H, Toda M, Ohira T, Yoshida K
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 124(1) Issue: 1 Pages: 127-135

    • DOI

      10.1007/s11060-015-1817-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PCR-based simple subgrouping is validated for classification of gliomas and defines negative prognostic copy number aberrations in IDH mutant gliomas2015

    • Author(s)
      Nakae S, Sasaki H, Hayashi S, Hattori N, Kumon M, Nishiyama Y, Adachi K, Nagahisa S, Hayashi T, Inamasu J, Abe M, Hasegawa M, Hirose Y
    • Journal Title

      PLoS ONE

      Volume: 10(11) Issue: 11 Pages: e0142750-e0142750

    • DOI

      10.1371/journal.pone.0142750

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳腫瘍における術前補助療法2014

    • Author(s)
      佐々木光、西山悠也、吉田一成
    • Journal Title

      癌と化学療法

      Volume: 41(6)

    • Related Report
      2013 Research-status Report
  • [Journal Article] Radiological features of supratentorial gliomas are associated with their genetic aberrations2014

    • Author(s)
      Nishiyama Y, Sasaki H, Nagahisa S, Adachi K, Hayashi T, Yoshida K, Kawase T, Hattori N, Murayama K, Abe M, Hasegawa M, Katada K, Hirose Y
    • Journal Title

      Neurosurg Rev

      Volume: 37(2) Issue: 2 Pages: 291-9

    • DOI

      10.1007/s10143-013-0515-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Supratentorial neurenteric cyst with spontaneous repetitive intracystic hemorrhage mimicking brain abscess: a case report2014

    • Author(s)
      Kitamura Y, Sasaki H, Hashiguchi A, Momoshima S, Shidoh S, Yoshida K
    • Journal Title

      Neurosurg Rev

      Volume: 37(1) Issue: 1 Pages: 153-159

    • DOI

      10.1007/s10143-013-0476-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subgrouping of gliomas on the basis of genetic profiles2013

    • Author(s)
      Hirose Y, Sasaki H, Abe M, Hattori N, Adachi K, Nishiyama Y, Nagahisa S, Hayashi T, Hasegawa M, Yoshida K
    • Journal Title

      Brain Tumor Pathology

      Volume: 30(4) Issue: 4 Pages: 203-208

    • DOI

      10.1007/s10014-013-0148-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.2013

    • Author(s)
      Kitamura Y, Sasaki H, Kimura T, Miwa T, Takahashi S, Kawase T, Yoshida K
    • Journal Title

      Journal of Neuropathology and Experimental Neurology

      Volume: 72(9) Issue: 9 Pages: 814-823

    • DOI

      10.1097/nen.0b013e3182a065d0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optic nerve seeding of atypical meningiomas presenting with subacute visual loss: two case reports with genetic characterization2013

    • Author(s)
      Kitamura Y, Akiyama T, Sasaki H, Hayashi Y, Yoshida K
    • Journal Title

      J Neurosurgery

      Volume: 119(2) Issue: 2 Pages: 494-498

    • DOI

      10.3171/2013.1.jns121533

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of radiologically multicentric but genetically identical multiple glioblastomas.2013

    • Author(s)
      Akimoto J, Sasaki H, Haraoka R, Nakajima N, Fukami S, Kohno M
    • Journal Title

      Brain Tumor Pathol

      Volume: Aug 11 (E pub)

    • Related Report
      2013 Research-status Report
  • [Journal Article] Surgical navigation-assisted endoscopic biopsy is feasible for safe and reliable diagnosis of unresectable solid brain tumors2013

    • Author(s)
      5 Nagahisa S, Watabe T, Sasaki H, Nishiyama Y, Hayashi T, Hasegawa M, Hirose Y
    • Journal Title

      Neurosurg Rev

      Volume: 36(4) Issue: 4 Pages: 595-601

    • DOI

      10.1007/s10143-013-0467-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 神経膠腫の分子診断と個別化治療2016

    • Author(s)
      佐々木光
    • Organizer
      Neuro Oncology Central 2016(招待講演)
    • Place of Presentation
      安保ホール(愛知県名古屋市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular classification and personalized treatment of gliomas(神経膠腫の分子生物学的分類と個別化治療)2015

    • Author(s)
      佐々木光
    • Organizer
      第20回新潟脳腫瘍研究会(招待講演)
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Glioblastoma長期生存例の分子生物学的解析を含めた検討2015

    • Author(s)
      中川 佑、佐々木光、戸田正博、大平貴之、河瀬 斌、吉田一成、尾原健太郎、亀山香織
    • Organizer
      第33回日本脳腫瘍学会
    • Place of Presentation
      グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2015-12-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular–genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss2015

    • Author(s)
      Hayashi S, Sasaki H, Kitamura Y, Hirose Y, Yoshida K
    • Organizer
      The 20th Annual Meeting of the Society for Neuro-Oncology(国際学会)
    • Place of Presentation
      San Antonio(USA)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Histopathological investigation of glioblastomas resected under neoadjuvant bevacizumab treatment2015

    • Author(s)
      Tamura R, Miyake K, Tanaka T, Tabei Y, Ohara K, Sampetrean O,Kohno M, Mizutani K, Yamamoto Y, Murayama Y, Tamiya T, Yoshida K, Sasaki H
    • Organizer
      The 20th Annual Meeting of the Society for Neuro-Oncology(国際学会)
    • Place of Presentation
      San Antonio(USA)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慶應義塾大学病院におけるグリオーマの治療2015

    • Author(s)
      佐々木光
    • Organizer
      第30回2007カンファレンス(招待講演)
    • Place of Presentation
      済生会横浜市東部病院研究室(神奈川県横浜市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] ベバシズマブ投与3日後の開頭手術の経験2015

    • Author(s)
      徳田佑紀奈、田村亮太、尾原健太郎、佐々木光、吉田一成
    • Organizer
      第127回日本脳神経外科学会関東支部学術集会
    • Place of Presentation
      ステーションコンファレンス万世橋(東京都千代田区)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Glioblastoma長期生存例の分子生物学的解析を含めた検討2015

    • Author(s)
      中川 佑、佐々木光、戸田正博、大平貴之、河瀬 斌、吉田一成、尾原健太郎、亀山香織
    • Organizer
      第16回日本分子脳神経外科学会
    • Place of Presentation
      アクトシティ浜松コングレンスセンター(静岡県浜松市)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性神経膠腫に対するベバシズマブ(BEV)術前化学療法:BEVコントロール下摘出腫瘍の病理組織学的検討2015

    • Author(s)
      田村亮太、三宅啓介、田中俊英、田部井勇介、尾原健太郎、河野まや、山本洋平、田宮 隆、佐々木光、吉田一成
    • Organizer
      第33回日本脳腫瘍病理学会
    • Place of Presentation
      JRホテルクレメント高松(香川県高松市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルキル化剤による腫瘍縮小後に摘出された神経膠腫標本における病理組織学的検討2015

    • Author(s)
      佐々木光、尾原健太郎、吉田一成
    • Organizer
      第33回日本脳腫瘍病理学会
    • Place of Presentation
      JRホテルクレメント高松(香川県高松市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 1p/19q codeleted gliomaにおける予後因子の検討

    • Author(s)
      林佐衣子、佐々木光、木村徳宏、亀山香織、中村 匠、北村洋平、三輪 点、廣瀬雄一、吉田一成
    • Organizer
      第31回日本脳腫瘍学会学術集会
    • Place of Presentation
      フェニックス・シーガイア・リゾート(宮崎県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Consideration of relationships between genetic abnormality and clinical picture inglioma without +7 and -1p/19q

    • Author(s)
      Adachi K, Sasaki H, Nagahisa S, Yoshida K, Hattori N, Nishiyama Y, Kawase T, Hasegawa M, Abe M, Hirose Y
    • Organizer
      4th Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Survey of the prognostic factors in 1p/19q codeleted gliomas

    • Author(s)
      Hayashi S, Sasaki H, Kimura T, Nakamura T, Miwa T, Hirose Y, Yoshida K
    • Organizer
      4th Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] None or little number of chromosomal aberrations detected by comparative genomic hybridization in fetal brain tumors

    • Author(s)
      Miwa T, Oi S, Nonaka Y, Sasaki H, Yoshida K
    • Organizer
      4th Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Neoadjuvant chemotherapy and staged removal of chemosensitive glioma based on preoperative molecular diagnosis by imaging characteristics

    • Author(s)
      Sasaki H, Nishiyama Y, Yoshida K, Hirose Y
    • Organizer
      4th Quadrennial Meeting of the World Federation of Neuro-Oncology
    • Place of Presentation
      サンフランシスコ(アメリカ)
    • Related Report
      2013 Research-status Report
  • [Presentation] 画像所見に基づく術前分子診断と化学療法感受性グリオーマの計画的摘出

    • Author(s)
      佐々木光、西山悠也、木村徳宏、吉田一成、廣瀬雄一
    • Organizer
      日本脳神経外科学会第72回学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Gliomaに対する遺伝子診断に基づくneoadjuvant approach

    • Author(s)
      佐々木光、廣瀬雄一、矢崎貴仁、片山 真、北村洋平、戸田正博、大平貴之、吉田一成
    • Organizer
      第18回日本脳腫瘍の外科学会
    • Place of Presentation
      大津プリンスホテル(岐阜県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Management of Gliomas According to Their Lineage Defined by Genetic Profiles

    • Author(s)
      Hirose Y, Sasaki H, Adachi K, Nagahisa S, Hayashi T, Nishiyama Y, Hattori N, Yamada Y, Hasegawa M, Yoshida K
    • Organizer
      15th World Congress of Neurosurgery
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭蓋底脊索腫の分子生物学的特徴と予後因子の検討

    • Author(s)
      北村洋平、佐々木光、木村徳宏、三輪 点、高橋里史、河瀬 斌、吉田一成
    • Organizer
      第25回日本頭蓋底外科学会
    • Place of Presentation
      名古屋東急ホテル(愛知県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 1p/19q codeleted glioma における分子生物学的特徴の検討

    • Author(s)
      林佐衣子、佐々木光、木村徳宏、中村 匠、三輪 点、廣瀬雄一、吉田一成
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      KFC Hall 国際ファッションセンター(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 組織診断および治療困難なtentorital tumor の一例

    • Author(s)
      中川 祐、佐々木光、林雄一郎、増田 勉、吉田一成
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      KFC Hall 国際ファッションセンター(東京都)
    • Related Report
      2013 Research-status Report
  • [Book] 脳神経外科学 改訂12版 II, 11章 脳腫瘍, 4 脳腫瘍各論 上衣系腫瘍2015

    • Author(s)
      佐々木光、尾原健太郎
    • Total Pages
      17
    • Publisher
      金芳堂
    • Related Report
      2015 Annual Research Report
  • [Remarks] グリオーマの遺伝子解析と個別化治療

    • URL

      http://www.neurosurgery.med.keio.ac.jp/medic/theme/brain_tumor_03.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] グリオーマの遺伝子解析と個別化治療

    • URL

      http://www.neurosurgery.med.keio.ac.jp/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi