Towards personalized treatment of gliomas -specifically to explore the indication of neoadjuvant chemotherapy for gliomas-
| Project/Area Number |
25462278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Hikaru 慶應義塾大学, 医学部, 講師 (70245512)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経膠腫 / 1p19q / 共欠失 / neoadjuvant / chemotherapy / 術前化学療法 / Glioma / neoadjuvant chemotherapy / 個別化治療 / 脳腫瘍 / 1p/19q |
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| Outline of Final Research Achievements |
Codeletion of chromosomes 1p and 19q is predictive for favorable prognosis in the patients with oligodendroglial tumors. We suggested that gliomas with 1p19q codeletion with some or more “astrocytic” features also had comparable biological and prognostic characteristics to those with oligodendroglial features (Oncotarget).
We showed that upfront chemotherapy for molecularly defined chemosensitive gliomas with the intension of second-look resection for initial incomplete resections might compare favorably with chemotherapy only, and suggested the usefulness of neoadjuvant strategy for the first time (J Neurooncol). We found that combination of surface localization and calcification strongly predicted 1p19q codeletion, and these radiological evaluation would help to segregate the candidates to be treated with neoadjuvant strategy (Neurosurg Rev).
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] PCR-based simple subgrouping is validated for classification of gliomas and defines negative prognostic copy number aberrations in IDH mutant gliomas2015
Author(s)
Nakae S, Sasaki H, Hayashi S, Hattori N, Kumon M, Nishiyama Y, Adachi K, Nagahisa S, Hayashi T, Inamasu J, Abe M, Hasegawa M, Hirose Y
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Journal Title
PLoS ONE
Volume: 10(11)
Issue: 11
Pages: e0142750-e0142750
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Radiological features of supratentorial gliomas are associated with their genetic aberrations2014
Author(s)
Nishiyama Y, Sasaki H, Nagahisa S, Adachi K, Hayashi T, Yoshida K, Kawase T, Hattori N, Murayama K, Abe M, Hasegawa M, Katada K, Hirose Y
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Journal Title
Neurosurg Rev
Volume: 37(2)
Issue: 2
Pages: 291-9
DOI
Related Report
Peer Reviewed
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[Presentation] Histopathological investigation of glioblastomas resected under neoadjuvant bevacizumab treatment2015
Author(s)
Tamura R, Miyake K, Tanaka T, Tabei Y, Ohara K, Sampetrean O,Kohno M, Mizutani K, Yamamoto Y, Murayama Y, Tamiya T, Yoshida K, Sasaki H
Organizer
The 20th Annual Meeting of the Society for Neuro-Oncology（国際学会）
Place of Presentation
San Antonio(USA)
Year and Date
2015-11-20
Related Report
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