Elucidation of the pain processing mechanism in the brain using Default mode network analysis
| Project/Area Number |
25462280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Meiji University of Integrative Medicine |
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Principal Investigator |
TANAKA CHUZO 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI TOSHIHIRO 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
UMEDA MASAHIRO 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 疼痛 / fMRI / 腰痛 / 関節包内運動 / 慢性疼痛 / default mode network / 仙腸関節 / 関節運動学的アプローチ |
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| Outline of Final Research Achievements |
It is the experiments which analyzed the brain function of a chronic low back pain using the f-MRI and default mode network (DMN). AKA-Hakata method, one of arthrokinematic approach (AKA) in Japan is used as treatment for pain relief. After anatomical and rs-fMRI measurements, all participants periodically received passive intra-articular movement in the right talono-vicular joint for a fMRI of the block paradigm. After the treatment, the anatomical, rs-fMRI, and block paradigm fMRI measurements were performed again. The modulatory effect of pain-relief manipulation therapy to the somatosensory evoked different response in S1 and DMN on chronic lumbago patients. It might be sustained attentional change or shift due to diminish painful sensation of lumbago after treatment, which is not synchronized passive intra-articular movement task, was caused disappearance activation.
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Report
(3 results)
Research Products
(22 results)
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[Presentation] Diffusion Tensor Spectroscopic Imaging of Multiple Metabolites in Rat Brains.2013
Author(s)
Bito Yoshitaka, Kawai Yuko, Hirata Koji, Ebisu Toshihiko, Otake Yosuke, Hirata Satosh, Shirai Toru, Soutome Yoshihisa, Ochi Hisaaki, Umeda Masahiro, Higuchi Toshihiro, Tanak, Chuzo
Organizer
International Society for Magnetic Resonance in Medicine 21st Annual Meeting & Exhibition
Place of Presentation
Salt Lake City
Related Report
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[Presentation] Diffusion-weighted Spectroscopic Imaging を用いた脳虚血モデルラットにおける 複数代謝物 ADC の解析2013
Author(s)
尾藤良孝, 河合裕子, 平田宏司, 恵飛須俊彦, 大竹陽介, 平田智嗣, 白猪 亨, 五月女悦久, 越智久晃, 梅田雅宏, 樋口敏宏, 田中忠蔵
Organizer
第41回日本磁気共鳴医学会大会
Place of Presentation
徳島
Related Report
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