Construction of mutanome database for malignant gliomas

• Project/Area Number: 25462281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kurume University
• Principal Investigator: Terasaki Mizuhiko 久留米大学, 医学部, 准教授 (70320223)
• Co-Investigator(Kenkyū-buntansha): SUGITA Yasuo 久留米大学, 医学部, 教授 (80216316)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脳腫瘍 / グリオーマ / 個別化ワクチン / 免疫逃避 / 治療効果 / 腫瘍免疫逃避 / エンドセリン

Outline of Final Research Achievements

For the purpose of novel therapeutic development personalized vaccine against glioma, we ew-wvaluated progression criteria with 15 enrolled glioma patients statistically. As a result, 54% in the WHO criteria, 43% increase in RECIST criteria were therapeutically mortality threshold. In addition, from clinical data, immunohistochemistry and RNA testing of 77 samples, cytokines and/or inflammatory responses were correlated to the the immune escape mechanism, furthermore clinical response of personalized vaccine therapy.

Research Products

• [Journal Article] Endothelin B receptor expression in malignant gliomas: the perivascular immune escape mechanism of gliomas (2016)
  • Author(s): Nakashima S, Sugita Y, Miyoshi H, Arakawa F, Muta H, Ishibashi Y, Niino D, Ohshima K, Terasaki M, Nakamura Y, Morioka M
  • Journal Title: Journal of Neuro-Oncology Volume: 127 Issue: 1 Pages: 23-32
  • DOI: 10.1007/s11060-015-2017-5
  • Peer Reviewed
• [Journal Article] Gliosarcomas arising from the pineal gland region: uncommon localization and rare tumors (2016)
  • Author(s): Sugita Y, Terasaki M, Tanigawa K, Ohshima K, Morioka M, Higaki K, Nakagawa S, Shimokawa S, Nakashima Susumu
  • Journal Title: Neuropathology Volume: 36 Issue: 1 Pages: 56-63
  • DOI: 10.1111/neup.12226
  • Peer Reviewed
• [Journal Article] A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis (2016)
  • Author(s): Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
  • Journal Title: Neuro-Oncology Practice Volume: 0 Issue: 4 Pages: 1-9
  • DOI: 10.1093/nop/npv064
  • Peer Reviewed / Open Access
• [Journal Article] Vaccination Therapy (2016)
  • Author(s): Terasaki M
  • Journal Title: Nihon Rinsho Volume: 0 Pages: 0-0
  • Peer Reviewed
• [Journal Article] Parent’s perceived provision of information regarding diagnosis to children with brain tumors (2015)
  • Author(s): Sato I, Higuchi A, Yanagisawa T, Mukasa A, Ida K, Sawamura Y, Sugiyama K, Saito N, Kumabe T, Terasaki M, Nishikawa R, Ishida Y, Kamibeppu K
  • Journal Title: Open Journal of Nursing Volume: 5 Issue: 05 Pages: 451-464
  • DOI: 10.4236/ojn.2015.55048
  • Peer Reviewed / Open Access
• [Journal Article] Anaplastic astrocytomas with abundant Rosenthal fibers in elderly patients: a diagnostic pitfall of high-grade gliomas (2013)
  • Author(s): Sugita Y, Nakashima S, Ohshima K, Terasaki M, Morioka M
  • Journal Title: Neuropathology Volume: 33 Issue: 5 Pages: 533-540
  • DOI: 10.1111/neup.12025
  • Peer Reviewed
• [Journal Article] Recurrent left frontal lobe cystic tumor in a 49-year-old woman (2013)
  • Author(s): Sugita Y, Nakashima S, Nakamura Y, Ohshima K, Terasaki M, Maruiwa H
  • Journal Title: Neuropathology Volume: 33 Issue: 6 Pages: 678-681
  • DOI: 10.1111/neup.12011
  • Peer Reviewed
• [Journal Article] 悪性脳腫瘍の治療－最新のトピックス 脳腫瘍の最新治療法 免疫療法（ワクチン） (2013)
  • Author(s): 寺崎瑞彦、森岡基浩
  • Journal Title: Clinical Neuroscience Volume: 31 Pages: 1190-1193
  • Peer Reviewed
• [Presentation] 長期的に脳室体外ドレナージを施行した小児例の検討 (2016)
  • Author(s): 竹重暢之、長田優衣、江藤朋子、内門久明、寺崎瑞彦、森岡基浩
  • Organizer: 第27回石打カンファレンス
  • Place of Presentation: おかやま（新潟県妙高市）
  • Year and Date: 2016-03-04
• [Presentation] 長期的に脳室体外ドレナージを施行した小児例の検討 (2015)
  • Author(s): 竹重暢之、長田優衣、坂田清彦、内門久明、寺崎瑞彦、森岡基浩
  • Organizer: 第74回日本脳神経外科学会総会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
  • Year and Date: 2015-10-14
• [Presentation] Long-term outcome and predictive prognostic factors of Atypical/Anaplastic meningiomas (2015)
  • Author(s): Sakata K, Takeshige N, Nakashima S, Terasaki M, Morioka M
  • Organizer: 15th Interim Meeting of the World Federation of Neurosurgical Societies
  • Place of Presentation: Rome Marriott Park Hotel（Rome)
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] 中枢神経系原発悪性リンパ腫におけるPD-1/PD-L1の発現と免疫チェックポイント制御による新規治療法の可能性 (2015)
  • Author(s): 杉田保雄、牟田紘子、中嶋一貴、大島孝一、小牧 哲、寺崎瑞彦、森岡基浩
  • Organizer: 第33回日本脳腫瘍病理学会
  • Place of Presentation: JRホテルクレメント（香川県高松市）
  • Year and Date: 2015-05-29
• [Presentation] 非典型的な画像所見と臨床経過を示したgliosarcomaの一例 (2015)
  • Author(s): 古賀誉久、中島慎治、杉田保雄、牟田紘子、大島孝一、長田優衣、寺崎瑞彦、森岡基浩
  • Organizer: 第33回日本脳腫瘍病理学会
  • Place of Presentation: JRホテルクレメント（香川県高松市）
  • Year and Date: 2015-05-29
• [Presentation] 悪性神経膠腫におけるendothelin B receptorの発現とその意義 (2013)
  • Author(s): 中島慎治、杉田保雄、大島孝一、寺崎瑞彦、森岡基浩
  • Organizer: 第31回日本脳腫瘍病理学会
  • Place of Presentation: 東京
• [Presentation] 再発グリオブラストーマに対する治療－新潮流の中におけるテーラーメイドペプチドワクチン療法の意義－ (2013)
  • Author(s): 寺崎瑞彦、森岡基浩、西川 亮、藤巻高光、成田善孝、杉山一彦
  • Organizer: 第18回日本脳腫瘍の外科学会
  • Place of Presentation: 大津
• [Presentation] HLA-A24陽性標準治療抵抗性神経膠芽腫に対するペプチドワクチン多施設共同無作為第III相比較試験（医師主導治験） (2013)
  • Author(s): 寺崎瑞彦、森岡基浩、西川 亮、藤巻高光、成田善孝、杉山一彦、栗栖 薫、青木友和、永根基雄、廣瀬雄一、井上 亨、竹島秀雄、冨永悌二、伊達 勲、隈部俊宏、伊東恭悟
  • Organizer: 第72回日本脳神経外科学会総会
  • Place of Presentation: 横浜
• [Presentation] 悪性神経膠腫の免疫回避機構の検討：特にendothelin B receptorの役割について (2013)
  • Author(s): 中島慎治、杉田保雄、大島孝一、中村普彦、寺崎瑞彦、森岡基浩
  • Organizer: 第72回日本脳神経外科学会総会
  • Place of Presentation: 横浜