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Construction of mutanome database for malignant gliomas

Research Project

Project/Area Number 25462281
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKurume University

Principal Investigator

Terasaki Mizuhiko  久留米大学, 医学部, 准教授 (70320223)

Co-Investigator(Kenkyū-buntansha) SUGITA Yasuo  久留米大学, 医学部, 教授 (80216316)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳腫瘍 / グリオーマ / 個別化ワクチン / 免疫逃避 / 治療効果 / 腫瘍免疫逃避 / エンドセリン
Outline of Final Research Achievements

For the purpose of novel therapeutic development personalized vaccine against glioma, we ew-wvaluated progression criteria with 15 enrolled glioma patients statistically. As a result, 54% in the WHO criteria, 43% increase in RECIST criteria were therapeutically mortality threshold. In addition, from clinical data, immunohistochemistry and RNA testing of 77 samples, cytokines and/or inflammatory responses were correlated to the the immune escape mechanism, furthermore clinical response of personalized vaccine therapy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Endothelin B receptor expression in malignant gliomas: the perivascular immune escape mechanism of gliomas2016

    • Author(s)
      Nakashima S, Sugita Y, Miyoshi H, Arakawa F, Muta H, Ishibashi Y, Niino D, Ohshima K, Terasaki M, Nakamura Y, Morioka M
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 127 Issue: 1 Pages: 23-32

    • DOI

      10.1007/s11060-015-2017-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gliosarcomas arising from the pineal gland region: uncommon localization and rare tumors2016

    • Author(s)
      Sugita Y, Terasaki M, Tanigawa K, Ohshima K, Morioka M, Higaki K, Nakagawa S, Shimokawa S, Nakashima Susumu
    • Journal Title

      Neuropathology

      Volume: 36 Issue: 1 Pages: 56-63

    • DOI

      10.1111/neup.12226

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis2016

    • Author(s)
      Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
    • Journal Title

      Neuro-Oncology Practice

      Volume: 0 Issue: 4 Pages: 1-9

    • DOI

      10.1093/nop/npv064

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vaccination Therapy2016

    • Author(s)
      Terasaki M
    • Journal Title

      Nihon Rinsho

      Volume: 0 Pages: 0-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parent’s perceived provision of information regarding diagnosis to children with brain tumors2015

    • Author(s)
      Sato I, Higuchi A, Yanagisawa T, Mukasa A, Ida K, Sawamura Y, Sugiyama K, Saito N, Kumabe T, Terasaki M, Nishikawa R, Ishida Y, Kamibeppu K
    • Journal Title

      Open Journal of Nursing

      Volume: 5 Issue: 05 Pages: 451-464

    • DOI

      10.4236/ojn.2015.55048

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anaplastic astrocytomas with abundant Rosenthal fibers in elderly patients: a diagnostic pitfall of high-grade gliomas2013

    • Author(s)
      Sugita Y, Nakashima S, Ohshima K, Terasaki M, Morioka M
    • Journal Title

      Neuropathology

      Volume: 33 Issue: 5 Pages: 533-540

    • DOI

      10.1111/neup.12025

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrent left frontal lobe cystic tumor in a 49-year-old woman2013

    • Author(s)
      Sugita Y, Nakashima S, Nakamura Y, Ohshima K, Terasaki M, Maruiwa H
    • Journal Title

      Neuropathology

      Volume: 33 Issue: 6 Pages: 678-681

    • DOI

      10.1111/neup.12011

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性脳腫瘍の治療-最新のトピックス 脳腫瘍の最新治療法 免疫療法(ワクチン)2013

    • Author(s)
      寺崎瑞彦、森岡基浩
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 1190-1193

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 長期的に脳室体外ドレナージを施行した小児例の検討2016

    • Author(s)
      竹重暢之、長田優衣、江藤朋子、内門久明、寺崎瑞彦、森岡基浩
    • Organizer
      第27回石打カンファレンス
    • Place of Presentation
      おかやま(新潟県妙高市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 長期的に脳室体外ドレナージを施行した小児例の検討2015

    • Author(s)
      竹重暢之、長田優衣、坂田清彦、内門久明、寺崎瑞彦、森岡基浩
    • Organizer
      第74回日本脳神経外科学会総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Long-term outcome and predictive prognostic factors of Atypical/Anaplastic meningiomas2015

    • Author(s)
      Sakata K, Takeshige N, Nakashima S, Terasaki M, Morioka M
    • Organizer
      15th Interim Meeting of the World Federation of Neurosurgical Societies
    • Place of Presentation
      Rome Marriott Park Hotel(Rome)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中枢神経系原発悪性リンパ腫におけるPD-1/PD-L1の発現と免疫チェックポイント制御による新規治療法の可能性2015

    • Author(s)
      杉田保雄、牟田紘子、中嶋一貴、大島孝一、小牧 哲、寺崎瑞彦、森岡基浩
    • Organizer
      第33回日本脳腫瘍病理学会
    • Place of Presentation
      JRホテルクレメント(香川県高松市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非典型的な画像所見と臨床経過を示したgliosarcomaの一例2015

    • Author(s)
      古賀誉久、中島慎治、杉田保雄、牟田紘子、大島孝一、長田優衣、寺崎瑞彦、森岡基浩
    • Organizer
      第33回日本脳腫瘍病理学会
    • Place of Presentation
      JRホテルクレメント(香川県高松市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性神経膠腫におけるendothelin B receptorの発現とその意義2013

    • Author(s)
      中島慎治、杉田保雄、大島孝一、寺崎瑞彦、森岡基浩
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 再発グリオブラストーマに対する治療-新潮流の中におけるテーラーメイドペプチドワクチン療法の意義-2013

    • Author(s)
      寺崎瑞彦、森岡基浩、西川 亮、藤巻高光、成田善孝、杉山一彦
    • Organizer
      第18回日本脳腫瘍の外科学会
    • Place of Presentation
      大津
    • Related Report
      2013 Research-status Report
  • [Presentation] HLA-A24陽性標準治療抵抗性神経膠芽腫に対するペプチドワクチン多施設共同無作為第III相比較試験(医師主導治験)2013

    • Author(s)
      寺崎瑞彦、森岡基浩、西川 亮、藤巻高光、成田善孝、杉山一彦、栗栖 薫、青木友和、永根基雄、廣瀬雄一、井上 亨、竹島秀雄、冨永悌二、伊達 勲、隈部俊宏、伊東恭悟
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 悪性神経膠腫の免疫回避機構の検討:特にendothelin B receptorの役割について2013

    • Author(s)
      中島慎治、杉田保雄、大島孝一、中村普彦、寺崎瑞彦、森岡基浩
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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