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Analysis of the mechanism underlying prevention of muscle fatigue by eldecalcitol, a new vitamin D3 analogue

Research Project

Project/Area Number 25462284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionAkita University

Principal Investigator

Miyakoshi Naohisa  秋田大学, 医学(系)研究科(研究院), 准教授 (90302273)

Co-Investigator(Kenkyū-buntansha) HONGO Michio  秋田大学, 医学部, 講師 (50375250)
KASUKAWA Yuji  秋田大学, 医学研究科, 講師 (60375285)
Research Collaborator SAKAI Sadaoki  
SHIRAISHI Ayako  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords筋・神経病学 / エルデカルシトール / 筋 / 筋張力 / 遺伝子
Outline of Final Research Achievements

Activated vitamin D3 analogues, such as alfacalcidol (ALF) and eldecalcitol (ELD), are used for the treatment of osteoporosis. In recent years, vitamin D3 has been considered effective for not only bones, but also skeletal muscles and reduced risk of falls. In this study, we administered ALF or ELD to glucocorticoid-treated osteoporotic rats for 2 or 4 weeks to evaluate their effects on bones and skeletal muscles. The bone mineral density (BMD) of the femur was measured. Muscle strength, fatigue, cross-sectional area (CSA), and gene expressions in the lower limb were also measured. After 2 weeks of ALF treatment, the BMD was increased. After 2 weeks of treatment with ELD, the BMD and muscle-related gene expressions were increased. After 4 weeks of treatment with ELD, the muscle strength, CSA, and BMD tended to be maintained.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid‑treated rats2016

    • Author(s)
      Hayato Kinoshita, Naohisa Miyakoshi, Yuji Kasukawa, Sadaoki Sakai, Ayako Shiraishi, Toyohito Segawa, Kentaro Ohuchi, Masashi Fujii, Chie Sato, Yoichi Shimada
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 34 Issue: 2 Pages: 171-178

    • DOI

      10.1007/s00774-015-0664-4

    • NAID

      120006364338

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 活性型ビタミンD3の筋 とバランス能力に対する効果 (シンポジウム)2015

    • Author(s)
      宮腰尚久、木下隼人、斉藤公男、粕川雄司、島田洋一
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山県
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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