New treatment for peripheral nerve defect: Direct lengthening of both nerve stumps.

Research Project

Project/Area Number	25462285
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	University of Tsukuba
Principal Investigator	HARA Yuki 筑波大学, 医学医療系, 講師 (30431688)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	末梢神経再生 / 末梢神経損傷 / 筋・神経病学
Outline of Final Research Achievements	We have developed a new treatment for peripheral nerve defects: nerve lengthening method. We have applied this method in a clinical setting in 2009, clinical cases brought some new challenges. This investigation aimed at making improvement nerve lengthening method. (1) Development of automated nerve lengthening system. Continuous nerve lengthening enabled by　automated system, is more efficient lengthening than intermittent manual lengthening. (2) Prevention of nerve adhesion during lengthening. We use platelet rich plasma(PRP) contains several different growth factors that can stimulate nerve regeneration and prevent nerve adhesion. In this study, there were no differences about nerve adhesion between PRP administration or not, but nerve regeneration was superior in PRP administration group. (3) Clinical research for patients have peripheral nerve gap continue in this study. We developed a new nerve lengthening device for birth palsy.