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Animal model of adolescent idiopathic scoliosis

Research Project

Project/Area Number 25462296
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

DOI TOSHIO  九州大学, 大学病院, 准教授 (60346799)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords側弯症 / 思春期 / 動物モデル / 胸郭 / モデル動物 / 後弯症 / 胸郭変形 / 思春期特発性側弯症 / 体幹変形 / 胸椎 / 健常人
Outline of Final Research Achievements

Adolescent Idiopathic Scoliosis, which dramatically worsens in the adolescent period, is characterized by the features of right thoracic scoliosis. To date, a variety of pathogenic factors have been proposed as a cause of idiopathic scoliosis, however, the cause remains unclear. One of the factors limiting elucidating the treatment method of idiopathic scoliosis has been the lack of a relevant animal model. We found that the anteroposterior chest dimension in patients with thoracic scoliosis was significantly smaller than that in normal people. By applying no surgical orthosis, we could established mouse model of scoliosis. In the future, we could develop a new concept orthosis or a new minimal invasive method for the treatment of scoliosis. Additionally, we found a new sagittal parameter to estimate the pelvic tilt, which is important for daily practice.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] A new sagittal parameter to estimate pelvic tilt using the iliac cortical density line and iliac tilt: a retrospective X-ray measurement study2015

    • Author(s)
      Toshio Doi, et al.
    • Journal Title

      Journal of Orthopaedic Surgery and Reserch

      Volume: 10:115 Issue: 1 Pages: 1-5

    • DOI

      10.1186/s13018-015-0262-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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