Epidemiological study for locomotive disorders (LOHAS)

• Project/Area Number: 25462298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: Konno Shinto 福島県立医科大学, 医学部, 教授 (70254018)
• Co-Investigator(Kenkyū-buntansha): SEKIGUCHI Miho 福島県立医科大学, 医学部, 准教授 (00381400) ; OTANI Koji 福島県立医科大学, 医学部, 教授 (50285029) ; KIKUCHI Shinichi 福島県立医科大学, 医学部, 理事長兼学長 (80045773)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 疫学調査 / 運動器 / 長期追跡調査 / 腰部脊柱管狭窄 / 生活の質 / 縦断研究 / 自然経過 / QOL / 硬膜管 / MRI / 運動器疾患 / 腰痛 / 生活の質（QOL)

Outline of Final Research Achievements

Lumbar spinal stenosis (LSS) is the one of the locomotive disorders. Little has been reported the relationship between the natural history of LSS in the community. The purpose of this study was to assess the change of prevalence for symptomatic LSS and the dural sac cross-sectional area (DCSA) of lumbar spine with symptomatic LSS in the 10-year follow-up. Overall, 67.8% of the LSS improved their symptoms over 10 years, while 10.0% of the non-LSS subjects switched to LSS. The low back pain related QOL and LSS symptoms were correlated over the 10-year period. All subscales of the health-related QOL were not related to LSS symptoms positive or negative. The amount of change in DCSA each disc level did not change among four groups for 10 years. There results suggested that a diagnosis based solely on stenosis of DCSA by MRI was insufficient the onset of LSS symptoms 10 years later.

Research Products

• [Journal Article] Prevalence of pterygium in a population in Northern Japan: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study. (2013)
  • Author(s): Tano T, Ono K, Hiratsuka Y, Fukuhara S, Murakami A, Yamada M.
  • Journal Title: Acta Ophthalmologica Volume: 91 Issue: 3
  • DOI: 10.1111/aos.12044
  • Peer Reviewed
• [Journal Article] Overactive bladder symptom severity is associated with falls in community-dwelling adults: LOHAS study. (2013)
  • Author(s): Kurita N, Yamazaki S, Fukumori N, Otoshi K, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Horie S, Konno S, Kikuchi S, Fukuhara S.
  • Journal Title: BMJ Open. Volume: 3;3(5) Issue: 5 Pages: e002413-e002413
  • DOI: 10.1136/bmjopen-2012-002413
  • NAID: 120005289842
  • Peer Reviewed
• [Presentation] Epidemiological study of lumbar spinal snotesis: 10 year community follow-up (2015)
  • Author(s): Igari T, OtaniK, Sekiguchi M, Kikuchi S, Konno S.
  • Organizer: ISSLS 42nd annual meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-06-08
  • Int'l Joint Research
• [Presentation] 地域住民における腰部脊柱管狭窄の自然経過-１０年フォローアップー. (2015)
  • Author(s): 猪狩貴弘、大谷晃司、関口美穂、紺野慎一
  • Organizer: 第451回福島医学会学術研究集会
  • Place of Presentation: 福島
  • Year and Date: 2015-05-28
• [Presentation] 地域住民における腰部脊柱管狭窄の自然経過-１０年フォローアップー (2015)
  • Author(s): 猪狩貴弘、大谷晃司、関口美穂、菊地臣一、紺野慎一
  • Organizer: 第44回日本脊椎脊髄病学会
  • Place of Presentation: 福岡
  • Year and Date: 2015-04-16