| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We have developed tissue-engineered nerve conduits in combination with iPS cells transplantation for peripheral nerve regeneration. In the present study, we reconstructed peripheral nerve gaps in mice using the nerve conduits coated with iPS cell-derived neurospheres and evaluated the teratoma formation and localization of engrafted cells histologically. The iPS cell-derived Schwann-like cells survived in the nerve conduits, especially around the distal nerve stump, until at least 14 days after transplantation. This finding suggests that transplanted Schwann-like cells derived from iPS cells may contribute to axon regeneration at the distal side. No teratomas were identified in the nerve conduits at 24 and 48 weeks after implantation.
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