A population-based cohort study on natural history of lumbar spinal stenosis: the Wakayama Spine Study

• Project/Area Number: 25462305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: Yamada Hiroshi 和歌山県立医科大学, 医学部, 准教授 (70275361)
• Co-Investigator(Kenkyū-buntansha): Yoshimura Noriko 東京大学, 医学部附属病院, 准教授 (60240355) ; Masatoshi Teraguchi 和歌山県立医科大学, 医学部, 博士研究員 (00554544) ; Nobuki Asai 和歌山県立医科大学, 医学部, 助教 (00621822) ; Ryouhei Kagotani 和歌山県立医科大学, 医学部, 学内助教 (00597081)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 腰部脊柱管狭窄症 / 疫学 / 自然経過 / 予後 / 危険因子 / 縦断的研究 / 脊椎 / 神経科学 / 地域住民コホート / 検診 / 核磁気共鳴画像法

Outline of Final Research Achievements

A large scale longitudinal population-based cohort study was conducted to elucidate natural history of lumbar spinal stenosis. 778 out of 1009 participants of 1st investigation which was held four years ago were enrolled in this study (a 77% follow-up rates). Interestingly only 37% out of symptomatic LSS participants in a baseline still had a symptom. Whereas, 27% out of radiological LSS participants in a baseline developed disease. As a result of statistical analysis, radiological abnormality was not identified as a risk factor of symptomatic LSS. Given this results of longitudinal study, LSS may be a self-limited disease that resolves spontaneously with or without specific treatment and conservative therapy should be considered as first priority in a daily practice.

Research Products

• [Journal Article] Radiographic natural course of lumbar degenerative spondylolisthesis and its risk factors related to the progression and onset in a 15-year community-based cohort study: the Miyama study. (2016)
  • Author(s): Enyo Y, Yoshimura N, Yamada H, Hashizume H, Yoshida M.
  • Journal Title: J Orthop Sci. Volume: 20 Issue: 6 Pages: 978-84
  • DOI: 10.1007/s00776-015-0759-8
  • Peer Reviewed
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study. (2015)
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: 33 Issue: 2 Pages: 221-229
  • DOI: 10.1007/s00774-014-0583-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The association of combination of disc degeneration, endplate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study (2015)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Nakagawa H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine J Volume: 15 Issue: 4 Pages: 622-628
  • DOI: 10.1016/j.spinee.2014.11.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Issue: 1 Pages: 104-110
  • DOI: 10.1016/j.joca.2013.10.019
  • Peer Reviewed
• [Journal Article] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: The Wakayama Spine Study. (2013)
  • Author(s): Ishimoto Y
  • Journal Title: Osteoarthritis and Cartilage Volume: 印刷中 Issue: 6 Pages: 783-788
  • DOI: 10.1016/j.joca.2013.02.656
  • Peer Reviewed
• [Journal Article] 腰椎椎間孔狭窄の診断学 (2013)
  • Author(s): 山田 宏
  • Journal Title: 関節外科 Volume: 34 Pages: 67-76
• [Journal Article] 診療の秘訣 腰椎手術が失敗する理由 (2013)
  • Author(s): 山田 宏
  • Journal Title: Modern Physician Volume: 33 Pages: 528-528
• [Journal Article] 腰椎椎間孔狭窄の診断のポイントとは？ (2013)
  • Author(s): 山田 宏 吉田宗人
  • Journal Title: Locomotive Pain Frontier Volume: 2 Pages: 42-43
• [Journal Article] 腰椎椎間孔狭窄の診断と治療 (2013)
  • Author(s): 山田 宏 吉田宗人
  • Journal Title: 関節外科 Volume: 32 Pages: 36-42
• [Presentation] Prevalence of modic changes in subjects with positive sagittal imbalance and its relationship to low back pain in a population-based cohort: The Wakayama Spine Study. (2015)
  • Author(s): Asai Y, Yoshimura N, Tsutsui S, Teraguchi M, Oka H, Yamada H, Hashizume H, Minamide A, Nakagawa Y, Muraki S, Akune T, Yoshida M
  • Organizer: 51th Scoliosis Research Society
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2015-09-30
  • Int'l Joint Research
• [Presentation] Relationship between age-related changes in the paravertebral and psoas muscles of the lumbar spine and low back pain: The Wakayama Spine Study. (2015)
  • Author(s): Hashizume H, Yoshimura N, Yamada H, Oka H, Iwahashi H, Sasaki T, Teraguchi M, Ishimoto Y, Nagata K, Kagotani R, Muraki S, Minamide A, Nakagawa Y, Yoshida M
  • Organizer: Spine Across the Sea
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-07-26
  • Int'l Joint Research
• [Presentation] Relationship between age-related changes in the paravertebral and psoas muscles of the lumbar spine and low back pain: The Wakayama Spine Study (2015)
  • Author(s): Hashizume H, Yoshimura N, Yamada H, Oka H, Iwahashi H, Sasaki T, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Minamide A, Nakagawa Y, Yoshida M
  • Organizer: 43rd Annual Meeting of the International Society for the Study of Lumbar Spine
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-06-08
  • Int'l Joint Research
• [Presentation] Relationship between bony spinal canal stenosis and the prevalence of clinical symptoms of lumbar spinal stenosis –The Wakayama Spine Study, (2015)
  • Author(s): Iwahashi H , Yoshimura N, Hashizume H, Yamada H, Oka H, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Minamide A, Nakagawa Y, Yoshida M
  • Organizer: 43rd Annual Meeting of the International Society for the Study of Lumbar Spine
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2015-06-08
  • Int'l Joint Research
• [Presentation] Assosiation Of Lumbar Spondylolisthesis With Low Back Pain And Symptomatic Lumbar Spinal Stenosis In A population-based Cohort: The Wakayama Spine Study (2015)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Organizer: World Spine Congress
  • Place of Presentation: Buenos Aires, Argentina
  • Year and Date: 2015-05-20
  • Int'l Joint Research
• [Presentation] Improved diagnostic accuracy of lumbar foraminal stenosis by use of three-dimensional MR imaging: comparison with conventional MR imaging (2013)
  • Author(s): Yamada H, Terada M, Iwasaki H, Endo T, Nakao S, Hashizume H, Minamide A, Nakagawa Y,Nishi H, Tsutsui S, Yoshida M
  • Organizer: International Society for the Study of the Lumbar Spine 2013, , the 40th annual meeting
  • Place of Presentation: Scottsdale, USA
• [Presentation] 腰椎神経根障害に対する3次元MRI (2013)
  • Author(s): 山田 宏 吉田宗人 橋爪 洋 南出晃人 中川幸洋 西 秀人 岩崎 博 筒井俊二 延與良夫 遠藤 徹
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
  • Invited
• [Presentation] 3次元MRIを用いた新しい腰椎椎間孔狭窄の診断基準 (2013)
  • Author(s): 山田 宏
  • Organizer: 第47回和歌山画像医学研究会
  • Place of Presentation: 和歌山市
  • Invited
• [Presentation] 新しい腰椎椎間孔狭窄の診断と治療 (2013)
  • Author(s): 山田 宏
  • Organizer: 第19回和歌山県有床診療所協議会
  • Place of Presentation: 和歌山市
  • Invited
• [Presentation] Prevalence and distribution of intervertebral disc degeneration in the spine in a population-based cohort in Japan: The Wakayama Spine Study (2013)
  • Author(s): Teraguchi M, Hashizume H, Yamada H, Muraki S, Yoshimura N, Yoshida M
  • Organizer: International Society for the Study of the Lumbar Spine 2013, the 40th annual meeting
  • Place of Presentation: Scottsdale, USA
• [Presentation] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: The Wakayama Spine Study (2013)
  • Author(s): Teraguchi M, Hashizume H, Yamada H, Muraki S, Yoshimura N, Yoshida M
  • Organizer: North America Spine Society 28th Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] 全脊柱MRIにおける変性椎間板の分布と有病率、関連因子について-The Wakayama Spine Study- (2013)
  • Author(s): 寺口真年 橋爪 洋 山田 宏 吉村典子 村木重之 吉田宗人
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
• [Presentation] Prevalence and distribution of intervertebral disc degeneration in the spine in a population-based cohort in Japan: The Wakayama Spine Study (2013)
  • Author(s): Teraguchi M, Hashizume H, Yamada H, Muraki S, Yoshimura N, Yoshida M
  • Organizer: 第42回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 宜野湾市
• [Presentation] 3次元MRIにおける腰椎椎間孔狭窄の新しい画像診断基準とその臨床的価値 (2013)
  • Author(s): 山田 宏 吉田宗人 橋爪 洋 南出晃人 中川幸洋 西 秀人 岩崎 博 筒井俊二 延與良夫 遠藤 徹 木岡雅彦 石元優々 瀧口 登 籠谷良平 寺口真年 寺田 正樹
  • Organizer: 第42回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 宜野湾市
• [Presentation] 画像診断上の腰部脊柱管狭窄の有病率と有症状者の頻度について: The Wakayama Spine Study (2013)
  • Author(s): 石元優々 吉村典子 村木重之 山田 宏 長田圭司 橋爪 洋 瀧口 登 南出晃人 岡 敬之 阿久根徹 吉田宗人
  • Organizer: 第42回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 宜野湾市
• [Presentation] 画像診断上の腰部脊柱管狭窄の有病率と有症状者の頻度について: The Wakayama Spine Study (2013)
  • Author(s): 石元優々 山田 宏 長田圭司 吉村典子 吉田宗人
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
• [Presentation] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the WakayamaSpine Study (2013)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Organizer: International Society for the Study of the Lumbar Spine 2013, the 40th annual meeting
  • Place of Presentation: Scottsdale, USA