| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
There was no basic research, which directly demonstrated the relationship between degeneration of the intervertebral disc (IVD) and low back pain. We developed a rat model, in which lumbar facetectomy resulted in delayed gait abnormality seen in the low back pain models, which were induced by direct injuries of the paravertebral muscle and IVD. In our model, spinal instability and IVD degeneration were observed at the affected level, but not compression of the neural tissues such as the cauda equina and nerve roots. A variable of drugs was administered orally or into the affected IVD in this model. However, only oral administration of pregabalin resulted in improvement of gait abnormality. Intervertebral degeneration was not recovered or regenerated after any drug administrations. In addition, spine fusion at the affected level didn’t improve gait abnormality. These results suggest that IVD degeneration does induce low back pain and that the mechanism is related to neuropathic pain.
|
