Analysis of the mechanism of intervertebral disc degeneration induced by passive cigarette smoking in rat model

Research Project

Project/Area Number	25462313
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Nihon University
Principal Investigator	UEI Hiroshi 日本大学, 医学部, 助教 (50451373)
Co-Investigator(Kenkyū-buntansha)	TOKUHASHI Yasuaki 日本大学, 医学部, 教授 (80188739)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	椎間板変性 / 喫煙 / 脊椎脊髄病学 / 腰痛
Outline of Final Research Achievements	We performed a proteomic analysis of rat degenerative intervertebral discs induced by passive cigarette smoking. Expression of apoptosis-related genes were up-regulated. We also investigated the therapeutic effect of dedifferentiated fat (DFAT) cell transplantation by intravenous administration in rat models of intervertebral disc degeneration. The results suggest that autologous implantation of DFAT cells suppress down-regulated expression of intervertebral disc genes.

Report

(3 results)