The mechanisms of elevated blood pNF-H, as a biomarker for neural disorders
Project/Area Number |
25462317
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | National Rehabilitation Center for Persons with Disabilities |
Principal Investigator |
Tobimatsu Yoshiko 国立障害者リハビリテーションセンター(研究所), 病院(併任研究所), 病院長 (20172174)
|
Co-Investigator(Kenkyū-buntansha) |
OGATA Toru 国立障害者リハビリテーションセンター(研究所)、病院(併任研究所), 障害者健康増進・運動医科学支援センター, センター長 (00392192)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | バイオマーカー / 脊髄損傷 / 細胞培養 |
Outline of Final Research Achievements |
We investigated the basic mechanisms of dynamics of serum phospho-neurofilament H subunit (pNF-H), a possible biomarker for evaluating damage to central nervous system. The dorsal ganglion culture experiment revealed that pNF-H seems to be released from contused axons. The simultaneous sampling from blood and cerebrospinal fluid showed that the level of pNF-H is 5 to 10 times higher in cerebrospinal fluid, but the ratio varies depending on the pathological conditions. These results indicate that in the evaluation of serum pNF-H level, clinicians should be aware that it may reflect the type of damage to nervous tissue and also coexisting inflammation which facilitates transfer of pNF-H into peripheral blood.
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Report
(3 results)
Research Products
(3 results)