| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We investigated the basic mechanisms of dynamics of serum phospho-neurofilament H subunit (pNF-H), a possible biomarker for evaluating damage to central nervous system. The dorsal ganglion culture experiment revealed that pNF-H seems to be released from contused axons. The simultaneous sampling from blood and cerebrospinal fluid showed that the level of pNF-H is 5 to 10 times higher in cerebrospinal fluid, but the ratio varies depending on the pathological conditions. These results indicate that in the evaluation of serum pNF-H level, clinicians should be aware that it may reflect the type of damage to nervous tissue and also coexisting inflammation which facilitates transfer of pNF-H into peripheral blood.
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