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Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates

Research Project

Project/Area Number 25462324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Watanabe Toshifumi  東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (60634053)

Co-Investigator(Kenkyū-buntansha) MUNETA Takeshi  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (50190864)
SEKIYA Ichiro  東京医科歯科大学, 再生医療研究センター, 教授 (10345291)
OKAWA Atushi  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30251507)
SOTOME Shinichi  東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教員 (20401391)
Research Collaborator KONDO Shimpei  東京医科歯科大学, 医歯(薬)学総合研究科, 大学院生
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsmesenchymal stem cells / synovium / meniscus / regeneration / primate / 滑膜幹細胞 / 集合体 / 半月板再生 / 霊長類
Outline of Final Research Achievements

We investigated whether transplantation of aggregates of autologous synovial MSCs promoted meniscal regeneration in aged primates. After the anterior halves of the medial menisci in both knees were removed, an average of 14 aggregates consisting of 250,000 synovial MSCs were transplanted onto the meniscus defect. No aggregates were transplanted to the opposite knee for the control. Meniscus and articular cartilage were analyzed macroscopically and histologically at 8 (n=3) and 16 weeks (n=4). The medial meniscus was larger and the histological score for the regenerated meniscus was better in the MSC group than in the control group in each primate at 8 and 16 weeks. Mankin’s score for the medial femoral condyle cartilage was better in the MSC group than in the control group in all primates at 16 weeks. Transplantation of aggregates of autologous synovial MSCs promoted meniscus regeneration and delayed progression of degeneration of articular cartilage in aged primates.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2016 2014

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates.2016

    • Author(s)
      Kondo S, Muneta T, Nakagawa Y, Koga H, Watanabe T, Tsuji K, Sotome S, Okawa A, Kiuchi S, Ono H, Mizuno M, Sekiya I
    • Journal Title

      J Orthop Res

      Volume: in press Issue: 6 Pages: 1274-1282

    • DOI

      10.1002/jor.23211

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Transplantation Of Aggregates Of Synovial Mesenchymal Stem Cells Promotes Meniscus Regeneration In Monkeys2016

    • Author(s)
      Kondo S, Muneta T, Nakagawa Y, Koga H, Watanabe T, Tsuji K, Sotome S, Okawa A, Kiuchi S, Ono H, Mizuno 2, Sekiya I.
    • Organizer
      Orthopaedic Research Society 2016 Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transplantation of aggregates of synovial mesenchymal stem cells promote meniscus regeneration in a monkey massive meniscal defect2014

    • Author(s)
      Shimpei Kondo,Takeshi Muneta,Toshihumi Watanabe,Ichro Sekiya,Atsushi Ookawa.
    • Organizer
      東京医科歯科大学 歯・骨関連疾患のグローバル研究センター国際シンポジウム
    • Place of Presentation
      東京医科歯科大学M&Dタワー2階
    • Related Report
      2013 Research-status Report
  • [Presentation] サルの内側半月板広範囲(前方1/2)切除モデルでの滑膜間葉系幹細胞集合体の移植は半月板再生を促進する2014

    • Author(s)
      近藤 伸平,渡邊 敏文、大川淳、宗田大
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都府医師会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Transplantation of aggregates of synovial mesenchymal stem cells promote meniscus regeneration in a monkey massive meniscal defect2014

    • Author(s)
      Shimpei Kondo、,Toshihumi Watanabe,Ichro Sekiya,Atsushi Ookawa、Takeshi Muneta.
    • Organizer
      The Orthopaedic Research Society 2014 Annual Meeting
    • Place of Presentation
      Hyatt Regency New Orleans, Louisiana
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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