New treatment strategy against bone and soft tissue sarcoma by combination of telomerase-specific oncolytic adenovirus
Project/Area Number |
25462333
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OZAKI Toshifumi 岡山大学, 医歯薬学総合研究科, 教授 (40294459)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ウイルス治療 / 肉腫 / 臨床応用 / sarcoma / telomelycin / telomescan / circulating tumor cell |
Outline of Final Research Achievements |
We previously developed an oncolytic adenovirus, OBP-301, in which the hTERT gene promoter drives the expression of the E1A and E1B genes. A phase I clinical trial of OBP-301 was conducted in the United States on patients with advanced solid tumors, and a phase II clinical trial is being conducted in our hospital on patients with advanced esophageal cancer. In this study, we revealed the cytopathic activity of OBP-301 in bone and soft tissue sarcoma cells. Moreover, OBP-301 enhanced chemosensitivity to doxorubicin and cisplatin in human osteosarcoma cells. The antitumor effect of OBP-301 was remarkable on human osteosarcoma orthotopic xenograft model; however, bone destruction could not be prevented by OBP-301 monotherapy. Combination treatment with OBP-301 and zoledronic acid showed a synergistic antitumor effect, and prevented bone destruction. Our data indicates that OBP-301 is a promising antitumor reagent for the treatment of bone and soft tissue sarcomas
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Report
(3 results)
Research Products
(13 results)
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[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
Author(s)
大森敏規, 山川泰明, 長谷井嬢, 田澤大, 尾崎修平, 杉生和久, 藤原智洋, 国定俊之, 浦田泰生, 藤原俊義, 尾﨑敏文
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山市
Year and Date
2015-10-22
Related Report
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[Presentation] ヒト骨肉腫細胞に対する腫瘍融解アデノウイルスとゾレドロン酸の併用効果2013
Author(s)
山川 泰明, 長谷井 嬢, 佐々木 剛, 尾崎 修平, 田澤 大, 吉田 晶, 武田 健, 国定 俊之, 浦田 泰生, 藤原 俊義, 尾崎 敏文
Organizer
第28回日本整形外科学会基礎学術集会
Place of Presentation
千葉市
Related Report
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