Biomaterial mechanical characters and environmental factors influencing biofilm formation
| Project/Area Number |
25462340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
YODA Itaru 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (40646775)
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| Co-Investigator(Kenkyū-buntansha) |
KOSEKI Hironobu 長崎大学, 医歯薬学総合研究科(医学系), 教授 (70457571)
OSAKI Makoto 長崎大学, 医歯薬学総合研究科(医学系), 教授 (20380959)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 感染 / バイオフィルム / 生体人工材料 / 感染症 |
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| Outline of Final Research Achievements |
When bacteria form biofilm on biomaterial surface, chemo-therapy with antibiotics is difficult, and surgeries for implant-related infection are required. We evaluated the efficacy of mechanical charactors of biomaterial and environmental factors inhibiting biofilm formation. The smooth and hydrophobic surface of biomaterial obstructed bacterial adherence. In addition to that, biofilm formation was inhibited in albumin rich environment at lower temperature. These finding will help us to prevent a postoperative implant-related infection and to treat the suffered patients.
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Report
(3 results)
Research Products
(32 results)
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[Presentation] 感染症と戦う整形外科医2015
Author(s)
小関弘展
Organizer
第1回、東埼玉骨・関節感染症研究会
Place of Presentation
埼玉県越谷市、ベルヴィギャザホール
Year and Date
2015-10-13
Related Report
Invited
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