Research for Molecular Target of Osteosarcoma treatment
Project/Area Number |
25462342
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kagoshima University |
Principal Investigator |
Setoguchi Takao 鹿児島大学, 医歯(薬)学総合研究科, 特任准教授 (40423727)
|
Co-Investigator(Kenkyū-buntansha) |
KOMIYA Setsuro 鹿児島大学, 医歯学域医学系, 教授 (30178371)
NAGANO Satoshi 鹿児島大学, 医歯学域医学系, 准教授 (50373139)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 骨肉腫 / Hedgehog / GLI2 / RPS3 / metastasis / 三酸化ヒ素 |
Outline of Final Research Achievements |
We researched the molecular target for osteosarcoma treatment. We found that Hedgehog pathway is upregulated in human osteosarcoma. Inhibition of GLI family zinc finger 2 (GLI2) prevent osteosarcoma invasion. Invasion assay showed that combination of arsenic trioxide (ATO) and vismodegib (SMO inhibitor) prevented invasion of human osteosarcoma cells. Xenograft model showed that combination of ATO and vismodegib prevented lung metastasis of osteosarcoma. We found that expression of ribosomal protein S3 (RPS3) is regulated by GLI2. RPS3 promoted the invasion of osteosarcoma cells. These findings suggest that GLI2-RPS3 pathway might be a new therapeutic target for osteosarcoma.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Combination of Hedgehog inhibitors and standard anticancer agents synergistically prevent osteosarcoma growth.2016
Author(s)
Saitoh Y, Setoguchi T, Nagata M, Tsuru A, Nakamura S, Nagano S, Ishidou Y, Nagao-Kitamoto H, Yokouchi M, Maeda S, Tanimoto A, Furukawa T, Komiya S.
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Journal Title
Int J Oncol.
Volume: 48
Issue: 1
Pages: 235-42
DOI
Related Report
Peer Reviewed
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[Journal Article] Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion.2015
Author(s)
Nagao-Kitamoto H, Setoguchi T, Kitamoto S, Nakamura S, Tsuru A, Nagata M, Nagano S, Ishidou Y, Yokouchi M, Kitajima S, Yoshioka T, Maeda S, Yonezawa S, Komiya S.
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Journal Title
Cancer Lett.
Volume: 356
Issue: 2
Pages: 855-861
DOI
Related Report
Peer Reviewed
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[Journal Article] GLI2 is a novel therapeutic target for metastasis of osteosarcoma.2015
Author(s)
Nagao-Kitamoto H, Nagata M, Nagano S, Kitamoto S, Ishidou Y, Yamamoto T, Nakamura S, Tsuru A, Abematsu M, Fujimoto Y, Yokouchi M, Kitajima S, Yoshioka T, Maeda S, Yonezawa S, Komiya S, Setoguchi T.
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Journal Title
Int J Cancer.
Volume: 136
Issue: 6
Pages: 1276-1284
DOI
Related Report
Peer Reviewed / Open Access
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