Identification and characterization of tumorigenic stem cells in epithelioid sarcoma
Project/Area Number |
25462355
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Fukuoka University |
Principal Investigator |
NISHIO Jun 福岡大学, 医学部, 講師 (90360304)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 類上皮肉腫 / 腫瘍幹細胞 / 軟部腫瘍 / 染色体異常 / 脂肪肉腫 |
Outline of Final Research Achievements |
Epithelioid sarcoma (EPS) is a highly malignant soft tissue tumor which is difficult to diagnose in some cases. EPS usually does not respond well to chemotherapy or radiotherapy; therefore, a novel therapeutic option needs to be developed. We analyzed the characteristics of cancer stem-like cells/cancer-initiating cells in EPS cell lines (FU-EPS-1 and SFT-8606). We isolated a subpopulation of cancer stem-like cells in the FU-EPS-1 cell line. In addition, we found that high-molecular weight glycoprotein CA125 would be a useful marker for monitoring the clinical course of EPS. Furthermore, we identified characteristic chromosomal aberrations in a variety of soft tissue tumors.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] SRC inhibitation represents a potential therapeutic strategy in liposarcoma2015
Author(s)
Sievers E, Trautmann M, Kindler D, Huss S, Gruenewald I, Dirksen U, Renner M, Mechtersheimer G, Pedeutour F, Aman P, Nishio J, Schildhaus HU, Kirfel J, Schirmacher P, Wardelmann E, Buettner R, Hartmann W
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Journal Title
Int J Cancer
Volume: 137
Pages: 2578-2588
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] High Expression of CD109 Antigen Regulates the Phenotype of Caneer Stem-Like Cells/Cancer-lnitiating Cells in the Novel Epithelioid Sarcoma Cell Line ESX and Is Related to Poor Prognosis of Soft Tissue Sarcoma.2013
Author(s)
Emori M, Tsukahara T, Murase M, Kano M, Murata K, Takahashi A, Kubo T, Asanuma H, Yasuda K, Kochin V, Kaya M, Nagoya S, Nishio J, Iwasaki H, Sonoda T, Hasegawa T, Torigoe T, Wada T, Yamashita T, Sato N.
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Journal Title
PLoS One.
Volume: 8
Issue: 12
Pages: e84187-e84187
DOI
Related Report
Peer Reviewed
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