Mechanisms of bone fragility in patients with rheumatoid arthritis

• Project/Area Number: 25462357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Takahata Masahiko 北海道大学, 医学(系)研究科(研究院), 講師 (40374368)
• Co-Investigator(Kenkyū-buntansha): SUDA Hiromi 千歳科学技術大学, 理工学部, 教授 (00574857) ; TODO Msahiro 北海道大学, 大学院工学研究院, 准教授 (10314402) ; AMIDUKA Norio 北海道大学, 大学院歯学研究院, 教授 (30242431)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨粗鬆症 / 関節リウマチ / ステロイド / 骨質異常 / 骨質 / 骨脆弱性

Outline of Final Research Achievements

To elucidate the cause of increased fragility fracture risk in patients with rheumatoid arthritis (RA), we compared bone quality and quality between RA patients and age and sex-matched postmenopausal non-RA patients using bone biopsy samples. Despite that there was no significant difference in bone mineral density between two groups, bone strength and toughness were significantly lower in RA group than in non-RA group. Deterioration in bone quality including the degree of mineralization and bone microstructure found in RA patients most likely associated with decreased bone mechanical properties.

Research Products

• [Journal Article] Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis. (2015)
  • Author(s): Shimizu T, Takahata M, Kameda Y, Endo T, Hamano H, Hiratsuka S, Ota M, Iwasaki N
  • Journal Title: Bone Volume: 79 Pages: 65-70
  • DOI: 10.1016/j.bone.2015.05.029
  • Peer Reviewed
• [Presentation] 関節リウマチでは皮質骨の骨質劣化により早期から骨脆弱性が生じる (2015)
  • Author(s): 清水智弘, 高畑雅彦
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山国際会議場（富山県 富山市）
  • Year and Date: 2015-10-22
• [Presentation] 関節リウマチでは早期から関節近傍皮質骨の骨質異常と骨脆弱性が生じる (2015)
  • Author(s): 清水智弘, 高畑雅彦
  • Organizer: 第33回日本骨代謝学会
  • Place of Presentation: 京王プラザホテル（東京都 新宿区）
  • Year and Date: 2015-07-23