Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
To elucidate the cause of increased fragility fracture risk in patients with rheumatoid arthritis (RA), we compared bone quality and quality between RA patients and age and sex-matched postmenopausal non-RA patients using bone biopsy samples. Despite that there was no significant difference in bone mineral density between two groups, bone strength and toughness were significantly lower in RA group than in non-RA group. Deterioration in bone quality including the degree of mineralization and bone microstructure found in RA patients most likely associated with decreased bone mechanical properties.
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