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Investigation of molecular mechanisms of chondrogenesis by platelet rich plasma

Research Project

Project/Area Number 25462358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Ikeda Toshiyuki  東京大学, 医学部附属病院, 助教 (80322759)

Research Collaborator MISHIMA Yuko  
TAKAYANAGI Syunsaku  
KAWABATA Michiru  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords多血小板血漿 / クリオプレシピテート / 軟骨分化 / 転写因子 / PDGFβ / EMX / SOX / 輸血療法 / 選択的スプライシング / SOXトリオ / 血小板由来増殖因子
Outline of Final Research Achievements

Platelet rich plasma (PRP) and cryoprecipitate induced chondrogenesis and cell growth into un-differentiated chondrocytic cell line ATDC5 and human mesenchymal stem cells (MSC). This data has shown a possibility that cryoprecipitate will be applicable for cartilage regeneration medicine as well as PRP. SOX6 and SOX9 played important roles on in vitro chondrogenesis induced by PRP or cryoprecipitate. PDGFβ was also identified as a causal molecule of cartilage differentiation and cell growth induced by PRP. We found that EMX1 and EMX2 were induced by SOX6 and SOX9 and could induce cartilage differentiation into ATDC5 and MSC.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Hedgehog-Gli activators direct osteo-chondrogenic function of bone morp hogenetic protein toward osteogenesis in the perichondrium.2013

    • Author(s)
      Hojo H, et al.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 14 Pages: 9924-9932

    • DOI

      10.1074/jbc.m112.409342

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel disease-modifying osteoarthritis drug candidate targeting Runx12013

    • Author(s)
      Yano, F. et al.
    • Journal Title

      Ann Rheum Dis.

      Volume: 72 Issue: 5 Pages: 748

    • DOI

      10.1136/annrheumdis-2012-201745

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 脳神経外科手術における自己血輸血の安全性・有効性 その12016

    • Author(s)
      高柳俊作、池田敏之 他
    • Organizer
      日本自己血輸血学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳神経外科手術における自己血輸血の安全性・有効性 その22016

    • Author(s)
      川端みちる、池田敏之 他
    • Organizer
      日本自己血輸血学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification and characterization of molecular basis of Del mutations in the Japanese population2015

    • Author(s)
      Mishima Y, Sato T, Ikeda T et al.
    • Organizer
      AABB
    • Place of Presentation
      Anaheim
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 東京大学医学部附属病院 輸血部

    • URL

      http://square.umin.ac.jp/traf-tky/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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