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Development of novel osteoporosis medication which focusses on the renin angiotensin system in osteocytes

Research Project

Project/Area Number 25462360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Morita Sadao  東京医科歯科大学, 医学部附属病院, 准教授 (20202426)

Co-Investigator(Kenkyū-buntansha) ASOU Yoshinori  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (50345279)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨細胞 / レニン・アンジオテンシン系
Outline of Final Research Achievements

In this study, we evaluated the role of renin angiotensin system in osteocytes by using osteocyte-specific RAS related gene-deficient mice. These conditional knockout mice showed that cortical bone mass is significantly increased. In contrast, trabecular bone mass was not changed. The expression of the osteoblast differentiation markers in the cortical bone in cKO mice is significantly increased. When the primary osteoblasts were co-cultured with RAS related gene knocked-down osteocytes, the osteoblasts activity was significantly increased. These results suggest that RAS related gene in osteocytes regulate indirectly the osteoblast activity and maintain the bone metabolism.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] 人工股関節全置換術におけるトラネキサム酸静脈内投与の効果と凝固線溶系に与える影響2015

    • Author(s)
      平尾昌之· 神野哲也· 古賀大介· 高田亮平· 瀬川裕子· 星野ちさと· 麻生義則· 森田定雄· 宗田大· 大川淳
    • Journal Title

      Hip Joint

      Volume: 41 Pages: 292-299

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.2013

    • Author(s)
      Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y.
    • Journal Title

      Scientific Report

      Volume: october 23 Issue: 1 Pages: 3022-3022

    • DOI

      10.1038/srep03022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ranges of active joint motion for the shoulder, elbow, and wrist in healthy adults2013

    • Author(s)
      Aizawa J, Masuda T, Hyodo K, Jinno T, Yagishita K, et al.
    • Journal Title

      Disability & Rehabilitation

      Volume: 35 Issue: 16 Pages: 1342-1349

    • DOI

      10.3109/09638288.2012.731133

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of Lower Limb Muscle Fatigue on Balance Function.2013

    • Author(s)
      Inoue K, Uematsu M, Maruoka H, hara K, Kanemura N, Masuda T, Morita S.
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 25 Pages: 331-335

    • NAID

      130004431963

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] セメントレス人工股関節全置換術後の大腿骨脆弱性骨折の特徴2015

    • Author(s)
      平尾昌之、神野哲也、木村晶理、高田亮平、麻生義則、森田定雄、宗田大、大川淳
    • Organizer
      日本股関節学会
    • Place of Presentation
      グランフロント大阪(大阪府大阪市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biochemical Changes that affect immature patella tendon and Fat Pad after eccentric contraction.2013

    • Author(s)
      Kokubun T, Kanemura N, Maejima H, Morita S, Takayanagi K.
    • Organizer
      WCPT-AWP & ACPT Congress 2013
    • Place of Presentation
      Taichung,Taiwan.
    • Related Report
      2013 Research-status Report
  • [Presentation] Early protective joint motion with anterior cruciate ligament complete rupture leads to natural healing.2013

    • Author(s)
      T. Kokubun, N. Kanemura, Y. Nishikawa, H. Maejima, S. Morita, K. Takayanagi.
    • Organizer
      7th World Congress of ISPRM 2013
    • Place of Presentation
      Beijing, China.
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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