| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this study, we evaluated the role of renin angiotensin system in osteocytes by using osteocyte-specific RAS related gene-deficient mice. These conditional knockout mice showed that cortical bone mass is significantly increased. In contrast, trabecular bone mass was not changed. The expression of the osteoblast differentiation markers in the cortical bone in cKO mice is significantly increased. When the primary osteoblasts were co-cultured with RAS related gene knocked-down osteocytes, the osteoblasts activity was significantly increased. These results suggest that RAS related gene in osteocytes regulate indirectly the osteoblast activity and maintain the bone metabolism.
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