The effect of anthocyanidin on skeletal antiaging

• Project/Area Number: 25462361
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Daisuke Koga 東京医科歯科大学, 医学部附属病院, 非常勤講師 (60422482)
• Co-Investigator(Kenkyū-buntansha): 麻生 義則 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50345279) ; 辻 邦和 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (20323694)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アントシアニジン / 腸内フローラ / 骨代謝 / 腸内細菌 / 変形性膝関節症 / ポリフェノール / 脂質代謝 / 軟骨代謝

Outline of Final Research Achievements

We disclosed anthocyanidin prevented osteoarthritis (OA) progression in a murine OA model.To explore the mechanisms of anti-inflammatory role of anthocyanidin, we have analysed the effect of oral administration of anthocyanidin to gut microbiota.

Research Products

• [Journal Article] Limited significance of screening computed tomography after cementless total hip arthroplasty with highly cross-linked polyethylene at 7-10 years of follow-up. (2016)
  • Author(s): Takada R, Jinno T, Koga D, Yamauchi Y, Asou Y, Muneta T, Okawa A.
  • Journal Title: Mod Rheumatol Volume: Ｆｅｂ１６ Pages: 1-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of Different Materials and Proximal Coatings Used for Femoral Components in One-Stage Bilateral Total Hip Arthroplasty. (2015)
  • Author(s): Miyatake K, Jinno T, Koga D, Yamauchi Y, Muneta T, Okawa A.
  • Journal Title: J Arthroplasty Volume: 30 Issue: 12 Pages: 2237-2241
  • DOI: 10.1016/j.arth.2015.06.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Is closed suction drainage effective in early recovery of hip joint function? Comparative evaluation in one-stage bilateral total hip arthroplasty. (2015)
  • Author(s): Koyano G, Jinno T, Koga D, Hoshino C, Muneta T, Okawa A
  • Journal Title: J Arthroplasty. Volume: 30 Issue: 1 Pages: 74-8
  • DOI: 10.1016/j.arth.2014.08.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Is Drain Tip Culture Prognostic of Surgical Site Infection? Results of 1380 Drain Tip Cultures in Total Hip Arthroplasty. (2015)
  • Author(s): Takada R, Jinno T, Koga D, Hirao M, Muneta T, Okawa A
  • Journal Title: J Arthroplasty. Volume: in press Issue: 8 Pages: 1407-1409
  • DOI: 10.1016/j.arth.2015.02.038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis. (2015)
  • Author(s): Ailixiding M, Aibibula Z, Iwata M, Piao J, Hara Y, Koga D, Okawa A, Morita S, Asou Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 466 Issue: 3 Pages: 319-326
  • DOI: 10.1016/j.bbrc.2015.09.019
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Initial Responses of Articular Tissues in a Murine High-Fat Diet-Induced Osteoarthritis Model: Pivotal Role of the IPFP as a Cytokine Fountain. (2013)
  • Author(s): Iwata M, Ochi H, Hara Y, Tagawa M, Koga D, Okawa A, Asou Y.
  • Journal Title: PLoS One Volume: 12 Issue: 4 Pages: e60706-e60706
  • DOI: 10.1371/journal.pone.0060706
  • Peer Reviewed
• [Presentation] Xanthine oxidase inhibitor febuxostat attenuate high fat diet-induced osteoarthritis. (2016)
  • Author(s): Zulipiya Aibibula*2, Maierhaba Ailixiding*1, Jinying Piao2 , Daisuke Koga2, Atsushi Okawa2, Yoshinori Asou2
  • Organizer: Ａｎｎｕａｌ ｍｅｅｔｉｎｇ ｆｏｒ Ｏｒｔｈｏｐａｅｄｉｃｓ Ｒｅｓｅａｒｃｈ Ｓｏｃｉｅｔｙ
  • Place of Presentation: フロリダ州オーランド（米国）
  • Year and Date: 2016-03-05
  • Int'l Joint Research
• [Presentation] 人工股関節全置換術後患者に対する静脈血栓塞栓症予防 術前リスクスコアリングによる抗凝固薬の用量調節の有用性 (2016)
  • Author(s): 吉原 有俊, 古賀 大介, 高田 亮平, 平尾 昌之, 宗田 大, 大川 淳, 神野 哲也
  • Organizer: 第46回日本人工関節学会
  • Place of Presentation: グランフロント大阪(大阪府大阪市）
  • Year and Date: 2016-02-26
• [Presentation] 人工股関節全置換術におけるトラネキサム酸静脈内投与の効果と凝固線溶系に与える影響 (2015)
  • Author(s): 平尾 昌之, 神野 哲也, 古賀 大介, 高田 亮平, 瀬川 裕子, 星野 ちさと, 麻生 義則, 森田 定雄, 宗田 大, 大川 淳
  • Organizer: 第42回日本股関節学会
  • Place of Presentation: グランフロント大阪（大阪府大阪市）
  • Year and Date: 2015-10-30
• [Presentation] メタボリックシンドロームと変形性膝関節症のクロストークにおけるサーチュイン遺伝子Sirt6の機能解析 (2015)
  • Author(s): 麻生 義則, Maierhaba Ailixiding, Zulipiya Aibibula, 朴 金瑛, 古賀 大介, 大川 淳, 森田 定雄
  • Organizer: 第30回日本整形外科基礎学術集会
  • Place of Presentation: 富山国際会議場（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] 高脂肪食誘導性変形性膝関節症におけるキサンチンオキシダーゼ(XOR)の機能解析 (2015)
  • Author(s): 麻生 義則, Zulipiya Aibibula, Maierhaba Ailixiding, 朴 金瑛, 金 光文, 古賀 大介, 大川 淳
  • Organizer: 第30回日本整形外科基礎学術集会
  • Place of Presentation: 富山国際会議場（富山県富山市）
  • Year and Date: 2015-10-22
• [Presentation] セメント使用/非使用の人工関節再置換術の選択 セメントレスカップによる人工股関節再置換術 (2015)
  • Author(s): 神野 哲也, 古賀 大介, 木村 晶理, 高田 亮平, 平尾 昌之, 星野 ちさと, 森田 定雄, 大川 淳, 宗田 大
  • Organizer: 第64回東日本整形災害外科学会
  • Place of Presentation: コラッセ福島（福島県福島市）
  • Year and Date: 2015-09-11
• [Presentation] The distinct role of the infrapatellar fat pad in a murine high-fat diet-induced osteoarthritis model.
  • Author(s): Munetaka Iwata1, Hiroki Ochi2, Yasushi Hara1, Masahiro Tagawa1, Daisuke Koga3, Atsushi Okawa3, Yoshinori Asou3
  • Organizer: Annual meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Ｂａｌｔｉｍｏｒｅ ＵＳＡ