The effect of anthocyanidin on skeletal antiaging
Project/Area Number |
25462361
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Daisuke Koga 東京医科歯科大学, 医学部附属病院, 非常勤講師 (60422482)
|
Co-Investigator(Kenkyū-buntansha) |
麻生 義則 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50345279)
辻 邦和 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (20323694)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | アントシアニジン / 腸内フローラ / 骨代謝 / 腸内細菌 / 変形性膝関節症 / ポリフェノール / 脂質代謝 / 軟骨代謝 |
Outline of Final Research Achievements |
We disclosed anthocyanidin prevented osteoarthritis (OA) progression in a murine OA model.To explore the mechanisms of anti-inflammatory role of anthocyanidin, we have analysed the effect of oral administration of anthocyanidin to gut microbiota.
|
Report
(3 results)
Research Products
(13 results)