Mechanism of articular cartilage repair and prevention of cartilage degeneration with tenascin C and application for treatment
Project/Area Number |
25462367
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUDO Akihiro 三重大学, 大学院医学系研究科, 教授 (60196904)
YOSHIDA Toshimichi 三重大学, 大学院医学系研究科, 教授 (80166959)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 関節軟骨 / テネイシン |
Outline of Final Research Achievements |
We implanted Gellan-GS soaked in TNC into full-thickness osteochondral defects of the patellar groove of rabbits. Histologically as well as macroscopically, we found satisfactory repair of cartilage. Using mice, full-thickness osteochondral defects were created and the defects were filled with TNC. Histologic study showed satisfactory repair of cartilage. In posttraumatic osteoarthritis model with transection of anterior cruciate ligament and medial collateral ligament, we performed intra-articular injection of TNC. TNC administration markedly protected the articular cartilage from proteoglycan depletion for 6 weeks. These studies indicated that TNC could promote cartilage repair and protect cartilage degeneration in vivo. Although TNC upregulated the expression of ADAMTS4, TNC downregulated the expression of ADAMTS5.
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Report
(3 results)
Research Products
(98 results)
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[Journal Article] Fibrin-related markers for diagnosing acute-, subclinical-,and pre-venous thromboembolism in patients with major orthopedic surgery.2016
Author(s)
Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Yamashita Y, Katayama N, Sudo A.
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Journal Title
Int J Hematol
Volume: 103(5)
Issue: 5
Pages: 560-566
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux2016
Author(s)
Ikejiri M, Wada H, Yamaguchi T, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Sakaguchi A, Matsumoto T, Ohishi K, Fujimoto N, Yamada N, Ito M, Katayama N, Sudo A
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Journal Title
Int J Hematol
Volume: 103
Issue: 5
Pages: 554-559
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The relationships among hemostatic markers, the withdrawal of fondaparinux due to a reduction in hemoglobin and deep vein thrombosis in Japanese patients undergoing major orthopedic surgery.2013
Author(s)
Hasegawa M, Wada H, Wakabayashi H, Yoshida K, Miyamoto N, Asanuma K, Matsumoto T, Ohishi K, Shimokariya Y, Yamada N, Uchida A, Sudo A.
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Journal Title
Clin Chim Acta
Volume: 425
Pages: 109-113
DOI
Related Report
Peer Reviewed
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[Journal Article] The efficacy of rebamipide add-on therapy in arthritic patients with COX-2 selective inhibitor-related gastrointestinal events: a prospective, randomized, open-label blinded-endpoint pilot study by the GLORIA study group.2013
Author(s)
Hasegawa M, Horiki N, Tanaka K, Wakabayashi H, Tano S, Katsurahara M, Uchida A, Takei Y, Sudo A
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Journal Title
Mod Rheumatol
Volume: in press
Pages: 1172-1178
DOI
Related Report
Peer Reviewed
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