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Contributing factors to periarticular osteoporosis in rheumatoid arthritis

Research Project

Project/Area Number 25462368
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyoto University

Principal Investigator

ITO Hiromu  京都大学, 医学(系)研究科(研究院), 准教授 (70397537)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords関節リウマチ / 傍関節性骨粗鬆 / ケモカイン / 機能障害 / 骨治癒 / 骨粗鬆症 / 関節軟骨
Outline of Final Research Achievements

In bone healing of the mouse femur, MCP-1, a chemokine, was expressed in the early phase, and its blockade delayed bone healing. These results indicate MCP-1 plays an important role in the early phase of bone healing.
Bone mineral density (BMD) of the distal end of the forearm in patients with rheumatoid arthritis (RA) was lower than that of the shaft of the forearm, and joint destruction of the hand and functional disability of the upper hand were independent predictors for lower BMD of the forearm. Therefore, juxtaarticular osteoporosis has strong impact in the joint destruction and function in patients with RA.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis2016

    • Author(s)
      Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S
    • Journal Title

      Osteoporosis International

      Volume: 27 Issue: 2 Pages: 691-701

    • DOI

      10.1007/s00198-015-3256-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 関節リウマチにおける前腕の傍関節骨粗鬆は関節破壊と機能障害に相関する2015

    • Author(s)
      岩田崇裕、伊藤宣、布留守敏、橋本求、藤井隆夫、寺尾知可史、小豆澤勝幸、濱本洋輔、三森経世、松田秀一
    • Organizer
      第17回日本骨粗鬆症学会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis2015

    • Author(s)
      Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S
    • Organizer
      The Annual European Congress of Rheumatology EULAR2015
    • Place of Presentation
      Rome(Italy)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-07-25   Modified: 2019-07-29  

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