Contributing factors to periarticular osteoporosis in rheumatoid arthritis

• Project/Area Number: 25462368
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: ITO Hiromu 京都大学, 医学(系)研究科(研究院), 准教授 (70397537)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 関節リウマチ / 傍関節性骨粗鬆 / ケモカイン / 機能障害 / 骨治癒 / 骨粗鬆症 / 関節軟骨

Outline of Final Research Achievements

In bone healing of the mouse femur, MCP-1, a chemokine, was expressed in the early phase, and its blockade delayed bone healing. These results indicate MCP-1 plays an important role in the early phase of bone healing.
Bone mineral density (BMD) of the distal end of the forearm in patients with rheumatoid arthritis (RA) was lower than that of the shaft of the forearm, and joint destruction of the hand and functional disability of the upper hand were independent predictors for lower BMD of the forearm. Therefore, juxtaarticular osteoporosis has strong impact in the joint destruction and function in patients with RA.

Research Products

• [Journal Article] Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis (2016)
  • Author(s): Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S
  • Journal Title: Osteoporosis International Volume: 27 Issue: 2 Pages: 691-701
  • DOI: 10.1007/s00198-015-3256-1
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 関節リウマチにおける前腕の傍関節骨粗鬆は関節破壊と機能障害に相関する (2015)
  • Author(s): 岩田崇裕、伊藤宣、布留守敏、橋本求、藤井隆夫、寺尾知可史、小豆澤勝幸、濱本洋輔、三森経世、松田秀一
  • Organizer: 第17回日本骨粗鬆症学会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2015-09-17
• [Presentation] Periarticular osteoporosis of the forearm correlated with joint destruction and functional impairment in patients with rheumatoid arthritis (2015)
  • Author(s): Iwata T, Ito H, Furu M, Hashimoto M, Fujii T, Ishikawa M, Yamakawa N, Terao C, Azukizawa M, Hamamoto Y, Mimori T, Akiyama H, Matsuda S
  • Organizer: The Annual European Congress of Rheumatology EULAR2015
  • Place of Presentation: Rome（Italy）
  • Year and Date: 2015-06-10
  • Int'l Joint Research