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Investigation of the relationship between bone formation and inflammatory signaling

Research Project

Project/Area Number 25462369
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionResearch Institute, Osaka Medical Center for Maternal and Child Health (2015)
Osaka University (2013)

Principal Investigator

Higuchi Chikahisa  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, その他 (40432421)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsosteoblast / Btk / CRP / MEK5 / MEK1 / MEK2 / 炎症シグナル / MAPK
Outline of Final Research Achievements

We investigated the relationship between inflammatory signaling and osteoblasts. Our data demonstrated that Bruton’s tyrosine kinase(Btk) and C reactive protein(CRP)/FcR signal pathways suppresseed the osteoblastic differentiation. In addition, mitogen-activated protein kinase (MAPK) kinase 5 (MEK5) also suppressed the osteoblastic differentiation.
The results in the present study suggested that small molecules to inhibit these signaling pathways might be candidate agents for the treatment of fracture or bone defect to accelerate bone formation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2013

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] MEK5 suppresses osteoblastic differentiation.2015

    • Author(s)
      Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 463 Issue: 3 Pages: 241-247

    • DOI

      10.1016/j.bbrc.2015.05.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hyaluronan inhibits BMP-induced osteoblast differentiation.2015

    • Author(s)
      Kaneko K, Higuchi C, Kunugiza Y, Yoshida K, Sakai T, Yoshikawa H, Nakata K.
    • Journal Title

      FEBS Lett.

      Volume: 589 Issue: 4 Pages: 447-454

    • DOI

      10.1016/j.febslet.2014.12.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bruton tyrosine kinase (Btk) suppresses osteoblastic differentiation.2015

    • Author(s)
      Kaneshiro S, Ebina K, Shi K, Yoshida K, Otsuki D, Yoshikawa H, Higuchi C.
    • Journal Title

      J Bone Miner Metab.

      Volume: 33 Issue: 5 Pages: 486-495

    • DOI

      10.1007/s00774-014-0612-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Bruton's tyrosine kinase suppresses the osteoblast differentiation2013

    • Author(s)
      Shoichi Kaneshiro, Chikahisa Higuchi, Kousuke Ebina, Kenrin Shi, Hideki Yoshikawa
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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