Investigation of the relationship between bone formation and inflammatory signaling
| Project/Area Number |
25462369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health (2015)
Osaka University (2013) |
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Principal Investigator |
Higuchi Chikahisa 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, その他 (40432421)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | osteoblast / Btk / CRP / MEK5 / MEK1 / MEK2 / 炎症シグナル / MAPK |
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| Outline of Final Research Achievements |
We investigated the relationship between inflammatory signaling and osteoblasts. Our data demonstrated that Bruton’s tyrosine kinase(Btk) and C reactive protein(CRP)/FcR signal pathways suppresseed the osteoblastic differentiation. In addition, mitogen-activated protein kinase (MAPK) kinase 5 (MEK5) also suppressed the osteoblastic differentiation.
The results in the present study suggested that small molecules to inhibit these signaling pathways might be candidate agents for the treatment of fracture or bone defect to accelerate bone formation.
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Report
(3 results)
Research Products
(4 results)
