Pathomechanisms of femoral head collapse in osteonecrosis
| Project/Area Number |
25462373
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 大腿骨頭壊死 / 骨頭圧潰 / SPECT/CT |
|---|
| Outline of Final Research Achievements |
We assessed the degree and location of the reparative process in early osteonecrosis of the femoral head based on single-photon emission computed tomography / computed tomography (SPECT/CT) with 99m technetium hydroxymethylene diphosphonate. Our result suggested that there may be a gradual increase in osteoblastic activity around the necrotic lesion in the period preceding collapse. In addition, osteoblastic activity at the lateral region of the femoral head seems to be highest around the occurrence of collapse.
Subchondral insufficiency fracture of the femoral head may be confused with osteonecrosis of the femoral head, mainly due to radiological overlap. SPECT/CT with Tc-99m hydroxymethylene diphosphonate distinguished between subchondral insufficiency fracture and osteonecrosis, indicating that SPECT/CT can serve as a supplemental diagnostic imaging modality for differentiating subchondral insufficiency fracture from osteonecrosis.
|
Report
(3 results)
Research Products
(10 results)
