| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
We established a new rabbit model of osteoporosis, which closely resembles obesity-induced reduced bone quality-type osteoporosis in humans. Domestic rabbits showing similar bone metabolism characteristics (bone remodeling) to humans were used and the osteoporotic changes were induced by feeding the animals with high fat-containing diet under conditions similar to those used for induction of liver cirrhosis or NASH. In the established model, NASH was successfully induced as well as atherosclerosis with atheromatous plaque formation. Additionally, we demonstrated obesity-induced reduction of bone strength due to decreased bone density and degradation of collagen, a tissue-specific component determining bone quality.
|
