Effects of fluoxetine on neuronal damage after cardiac arrest/ cardiopulmonary resuscitation
| Project/Area Number |
25462398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中山 慎 筑波大学, 医学医療系, 講師 (60596443)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Makoto 筑波大学, 医学医療系, 教授 (50236634)
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| Research Collaborator |
ISAKA Yumi
NAKAMURA Takako
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 蘇生後脳症 / 全脳虚血 / フルオキセチン / 心肺停止 / 神経保護 / 神経新生 |
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| Outline of Final Research Achievements |
Several clinical studies have indicated that serotonin re-uptake inhibitor administration after acute ischemic stroke can improve clinical recovery. Fluoxetine (FLX: one of the serotonin re-uptake inhibitor) has several mechanisms which contribute to relieve the ischemic brain damage. The goal of this study is to evaluate the neuroprotective effect of FLX for a long observation period after cardiac arrest and cardiopulmonary resuscitation in mice. Fourteen days after ischemia, FLX did not have an influence on the number of survival neurons in hippocampus. However, FLX administration increased the number of immature neurons. At this time point, memory function improved in FLX group.
Fluoxetine improved memory function after cardiac arrest. This recovery may be due to neurogenesis in hippocampus, but not due to surviving neurons. Further investigation is needed to clarify the interaction of memory function and neurogenesis after fluoxetine administration.
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Report
(4 results)
Research Products
(5 results)
