| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Adrenomedullin (ADM) 2, 5 is subtype of mammalian ADM and implicated in the regulation of circulatory homeostasis and the pathophysiology of various diseases including septic shock, congestive heart failure, hepatic cirrhosis, chronic renal failure. We studied the effects of sevoflurane and propofol on ADM 2, 5 induced vasodilation in pithed rats, ADM receptor-mediated responses in SK-N-MC cells, which are used as a model system to study the ADM receptor and its downstream pathways, and the production of inflammatory mediators and endothelial function in rat sepsis model. Both anesthetics dose-dependently inhibited ADM-induced vasodilatory response in pithed rats. The inhibitory site of both anesthetics on those response would involve Gs protein between the ADM receptor and adenylate cyclase activation, while endothelial function might not be preserved by anesthetics in sepsis.
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