| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
We established the experimental procedures mainly using mice. The hypnotic endpoint was evaluated by a loss of righting reflex and a recovery of it. We obtained results that explain a part of the mechanism of action of general anesthetic through detailed analysis of interaction of various anesthetic agents. Especially, we examined the interaction between propofol and non-benzodiazepine hypnotics called as JM-1232(-), developed in Japan recently and found the new profile of general anesthesia by co-administration of both drugs. These achievements are announced at the international conference and are currently posting.
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