Relationship between the neuroprotection by brain hypothermia and the temporal IL-23 - IL-17 production by immune cells
| Project/Area Number |
25462403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MATSUI Tomohiro 山口大学, 医学(系)研究科(研究院), 講師 (50314828)
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| Co-Investigator(Renkei-kenkyūsha) |
KIDA Hiroyuki 山口大学, 大学院医学系研究科, 助教 (70432739)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳低温療法 / T細胞 / インターロイキン17 / グランザイムB / 高温培養 / ニューロン死 / 脳血管内皮細胞 / 脳高温 / IL-17 / 低酸素性虚血性脳障害 / IL-23 / 低温培養 |
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| Outline of Final Research Achievements |
T cells infiltrate into the infarcted brain within days after cerebral ischemia and play essential roles in exacerbating the delayed phase of the brain injury by producing pro-inflammatory factors. However, the involvement of these factors in brain damage is also demonstrated systemically. Such periphery-brain abnormalities are interesting because they may constitute a pathway to the central nervous system, which may be a target of therapeutic hypothermia. We examined the effects of hypothermia and hyperthermia on peripheral T cell-derived release of IL-17 and granzyme B (GrB). As a result, compared with normothermia, IL-17 and GrB release was reduced by hypothermia but augmented by hyperthermia. Moreover, IL-17 and GrB caused the death of neuronal cells in a concentration-dependent manner. These results suggest that the attenuation of T cell-derived release of IL-17 and GrB by therapeutic hypothermia leads to the inhibition of neuronal cell death in the delayed phase of brain injury.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Spinal Cord Ischemia/Injury2014
Author(s)
T Ishikawa, H Suzuki, K Ishikawa, S Yasuda, T Matsui, M Yamamoto, T Kakeda, S Yamamoto, Y Owada, TL Yaksh
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Journal Title
Current Pharmaceutical Design
Volume: 20
Issue: 36
Pages: 5738-5743
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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