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The effects of remifentanil on volatile anesthetics-induced myocardial protection and antiinflammatory effect

Research Project

Project/Area Number 25462404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionThe University of Tokushima

Principal Investigator

TANAKA Katsuya  徳島大学, 大学院医歯薬学研究部, 教授 (30263841)

Co-Investigator(Kenkyū-buntansha) OSHITA Shuzo  徳島大学, 大学院医歯薬学研究部, 非常勤講師 (60144945)
TSUTSUMI Yasuo  徳島大学, 大学院医歯薬学研究部, 准教授 (90523499)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords吸入麻酔薬 / 薬理学 / ストレス / レミフェンタニル / 心筋保護効果 / プレコンディショニング / NO / 心保護効果
Outline of Final Research Achievements

Using the myocardial ischemia and reperfusion model in vivo rabbit, we studied whether remifentanil, inhalation anesthetic isoflurane and remifentanil and isoflurane combination decreased myocardial infarction size as compared with the control group. As a result, remifentanil, the isoflurane significantly showed myocardial protection effect, respectively. In addition, the combination of both showed myocardial protection effect, but there was no significant difference between groups. NO inhibitor made myocardial protection effect disappear from different experiment. Therefore, it was suggested that NO was involved in the mechanism of action. This study showed that combination of commonly used remifentanil and inhalation anesthetic showed myocardial protection effect and this study elucidated a part of the mechanism of this action.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolin-3 expression.2015

    • Author(s)
      Hamaguchi E, Tanaka K, Tsutsumi R, Sakai Y, Fukuta K, Kasai A, Tsutsumi YM.
    • Journal Title

      Eur Rev Med Pharmacol Sci

      Volume: 19 Pages: 1285-1290

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Opioid-induced Cardioprotection2014

    • Author(s)
      Katsuya Tanaka, Judy R. Kersten, Matthias M. Riess
    • Journal Title

      Current Pharmaceutical Design

      Volume: 20 Issue: 36 Pages: 5696-5705

    • DOI

      10.2174/1381612820666140204120311

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 吸入麻酔薬による臓器保護効果2015

    • Author(s)
      田中克哉 川西良典 角田奈美 堤保夫
    • Organizer
      日本麻酔科学会 中国四国支部第52回学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プレコンの最前線 麻酔科医の立場から2015

    • Author(s)
      田中克哉
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸ポートピアホテル (兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 徳島大学教育研修者総覧 田中克哉

    • URL

      http://pub2.db.tokushima-u.ac.jp/ERD/person/60304/profile-ja.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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