The effects of remifentanil on volatile anesthetics-induced myocardial protection and antiinflammatory effect

• Project/Area Number: 25462404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: TANAKA Katsuya 徳島大学, 大学院医歯薬学研究部, 教授 (30263841)
• Co-Investigator(Kenkyū-buntansha): OSHITA Shuzo 徳島大学, 大学院医歯薬学研究部, 非常勤講師 (60144945) ; TSUTSUMI Yasuo 徳島大学, 大学院医歯薬学研究部, 准教授 (90523499)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 吸入麻酔薬 / 薬理学 / ストレス / レミフェンタニル / 心筋保護効果 / プレコンディショニング / ＮＯ / 心保護効果

Outline of Final Research Achievements

Using the myocardial ischemia and reperfusion model in vivo rabbit, we studied whether remifentanil, inhalation anesthetic isoflurane and remifentanil and isoflurane combination decreased myocardial infarction size as compared with the control group. As a result, remifentanil, the isoflurane significantly showed myocardial protection effect, respectively. In addition, the combination of both showed myocardial protection effect, but there was no significant difference between groups. NO inhibitor made myocardial protection effect disappear from different experiment. Therefore, it was suggested that NO was involved in the mechanism of action. This study showed that combination of commonly used remifentanil and inhalation anesthetic showed myocardial protection effect and this study elucidated a part of the mechanism of this action.

Research Products

• [Journal Article] Exendin-4, glucagon-like peptide-1 receptor agonist, enhances isoflurane-induced preconditioning against myocardial infarction via caveolin-3 expression. (2015)
  • Author(s): Hamaguchi E, Tanaka K, Tsutsumi R, Sakai Y, Fukuta K, Kasai A, Tsutsumi YM.
  • Journal Title: Eur Rev Med Pharmacol Sci Volume: 19 Pages: 1285-1290
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Opioid-induced Cardioprotection (2014)
  • Author(s): Katsuya Tanaka, Judy R. Kersten, Matthias M. Riess
  • Journal Title: Current Pharmaceutical Design Volume: 20 Issue: 36 Pages: 5696-5705
  • DOI: 10.2174/1381612820666140204120311
  • Peer Reviewed
• [Presentation] 吸入麻酔薬による臓器保護効果 (2015)
  • Author(s): 田中克哉 川西良典 角田奈美 堤保夫
  • Organizer: 日本麻酔科学会 中国四国支部第５２回学術集会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] プレコンの最前線 麻酔科医の立場から (2015)
  • Author(s): 田中克哉
  • Organizer: 日本麻酔科学会第６２回学術集会
  • Place of Presentation: 神戸ポートピアホテル （兵庫県神戸市）
  • Year and Date: 2015-05-28
  • Invited
• [Remarks] 徳島大学教育研修者総覧 田中克哉
  • URL: http://pub2.db.tokushima-u.ac.jp/ERD/person/60304/profile-ja.html