|Budget Amount *help
¥4,680,000 (Direct Cost : ¥3,600,000、Indirect Cost : ¥1,080,000)
Fiscal Year 2015 : ¥1,170,000 (Direct Cost : ¥900,000、Indirect Cost : ¥270,000)
Fiscal Year 2014 : ¥1,690,000 (Direct Cost : ¥1,300,000、Indirect Cost : ¥390,000)
Fiscal Year 2013 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
|Outline of Final Research Achievements
The neuropathic pain model rats exhibit pain behaviour in 2 to 3 weeks after surgery. The phenomenon that down regulation of KCC2 and relative up regulation of NKCC1 has been proposed as promising mechanism underlying pain behaviour. We examined two models, SNL and CCI. While SNL rats did not exhibit the down regulation of KCC2, CCI showed the down regulation of pKCC2 in spinal dorsal horn, which is consistent with pain behaviour examined with weight distribution test. However the administration of CLP290, KCC2 activator, did not rescue pain behaviour.