The study to clarify the excitatory effect of anesthetics on neuronal toxicity in the neonatal brain

• Project/Area Number: 25462408
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: ISHIWA Dai 横浜市立大学, 医学研究科, 客員准教授 (30457858)
• Co-Investigator(Kenkyū-buntansha): 安藤 富男 横浜市立大学, 医学研究科, 客員教授 (00193110) ; 紙谷 義孝 新潟大学, 医歯学総合病院, 特任教授 (90381491)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 麻酔薬 / 幼若脳 / アポトーシス / KCC2 / 神経伝達物質 / プロポフォール / ブメタニド

Outline of Final Research Achievements

It has been reported that anesthtic agents induce apoptosis abundantly over the brain in the neonate but its mechanisims remain unknown.The GABAA stimulants induce neuronal depolarization and have excaitatory effects in cortex and hippocampus. Due to these effects, neurons may lead to neuronal death.
In this study we clarify neonatal administration of midazolam disrupt learning ability in the adolescent and this effect can be rescued by CLP290.