| Project/Area Number |
25462409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
OGAWA Kenichi 横浜市立大学, 医学(系)研究科(研究院), 客員准教授 (10233412)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIMOTO Kazuhiro 横浜市立大学, 医学研究科, 客員講師 (50710951)
GOTO Takahisa 横浜市立大学, 医学研究科, 教授 (00256075)
KAMIYA Yoshinori 新潟大学, 医歯薬総合病院, 教授 (90381491)
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| Research Collaborator |
MIYAZAKI Tomoyuki
MIHARA Takahiro
TOMINAGA Yosuke
ASAKURA Ayako
YUBA Yuki
YONEZAKI Kumiko
ADACHI Akiko
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 全身麻酔 / 吸入麻酔薬 / 術後疼痛 / 長期増強 / AMPA受容体 / 神経可塑性 / 認知記憶障害 / 海馬 / 急性侵害性疼痛 / 記憶学習 / 抑制性回避学習 / グルタミン酸受容体 / 術後痛 / 術後認知記憶障害 |
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| Outline of Final Research Achievements |
General surgery using volatile anesthetics may induce post operative cognitive disfunction.We made an acute postoperative pain and insult model using young adult rats for comprehensive elucidation of postoperative cognitive dysfunction (POCD).Our simple laparotomy model shows that acute postoperative pain may not affect hippocampus and learning, although volatiles anesthesia during only 5 minutes for laparotomy may affect hippocampus dependent learning and modulation of hippocampal GluA1 subunit of AMPAR.
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