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Elucidation of the pathogenesis of brain white matter injury caused by perioperative hypoxic ischemia and the development of regeneration therapy

Research Project

Project/Area Number 25462410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionNagoya City University

Principal Investigator

KAKO Eisuke  名古屋市立大学, 医学(系)研究科(研究院), 研究員 (70464576)

Co-Investigator(Kenkyū-buntansha) SASANO Hiroshi  名古屋市立大学, 大学院医学研究科, 教授 (20215742)
SOBUE Kazuya  名古屋市立大学, 大学院医学研究科, 教授 (90264738)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords再生医療 / 白質傷害 / 小児 / 周術期 / 白質脳症 / オリゴデンドロサイト / オリゴデンドロサイト前駆体 / 脳傷害 / 新生児
Outline of Final Research Achievements

Brain white matter injury in the perioperative period of childhood has a high frequency is no cure. First, we create a brain white matter injury model using a newborn mouse. The immature brain, oligodendrocyte progenitor cells (OPC) moved to the ischemic site by cerebral ischemia, but were found not to differentiate. Therefore, we adopted the asialo-erythropoietin (EPO) as a promoting factor of differentiation. In cultured cells and brain white matter injury model, differentiation from the OPC to oligodendrocytes has been promoted by the EPO. As a treatment for white matter injury by cerebral ischemia, the moving of endogenous OPC and promoting differentiation by and EPO has a possibility of clinical application.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives.2013

    • Author(s)
      Kaneko N, Kako E, Sawamoto K.
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 7 Pages: 235-235

    • DOI

      10.3389/fncel.2013.00235

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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