| Project/Area Number |
25462411
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
KOUMURA Hidefumi 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (20347404)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SASANO Hiroshi 名古屋市立大学, 大学院医学研究科, 教授 (20215742)
SOBUE Kazuya 名古屋市立大学, 大学院医学研究科, 教授 (90264738)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 脳浮腫 / アクアポリン / 脳虚血 / アストロサイト |
|---|
| Outline of Final Research Achievements |
The mechanism of the development of brain edema is complex and it is not yet clear. AQP4, one of a water channel aquaporin (AQP), has been suggested the importance in the development or recovery. On the other hand, AQP9 exists in the brain; pia, hippocampus, white matter. It was found to be relatively expressed in astrocytes by detailed study. In cultured astrocytes, AQP9 expression was increased through the P38PAMK and PKA, was reduced through the PKC. Hypoxia, AQP9 decreases, expressed and re-oxygen decreased. Expression of AQP9 in the cerebral artery ligation model in rats was increased. Since the regulation mechanisms of AQP9 expression were revealed, it can be a therapeutic target in the brain edema.
|
