The regulatory mechanism of cerebral microvessels and calcium signaling through astrocyte in hypertension

• Project/Area Number: 25462412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Kansai Medical University (2015); Wakayama Medical University (2013)
• Principal Investigator: Nakahata Katsutoshi 関西医科大学, 医学部, 講師 (70332971)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 血管平滑筋 / 高血圧 / 妊娠高血圧症候群 / 脳血管

Outline of Final Research Achievements

The cerebral microcirculation has a central role in supporting the neurological activity, yet our understanding how anesthesia affect the regulation mechanisms of local cerebral blood flow is extremely limited. We investigated the role of astrocyte in neurovascular coupling especially in patients with hypertension.