| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Outline of Final Research Achievements |
Although propofol has a possibility to induce dependence mediated by brain reward system, the precise mechanism of propofol dependence is unclear. The aim of this study was making a model of propofol dependence in rodent, clarifying the role of dopamine of brain reward systems in propofol dependent model, and validating the increase of some type of miRNA in brain reward system. We had indeed succeeded to induce propofol dependence in mice behavior test, but dopamine and miRNAs (miR-212) in brain reward system including nucleus accumbens or dorsal striatum were not increased. Propofol has a possibility to induce dependence but its mechanism was not clarified.
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