Study on the mechanism of the volatile anesthetics and the influence on the developing brain in the neural network.
| Project/Area Number |
25462415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 吸入麻酔薬 / セボフルラン / 線条体 / コリナージック細胞 / 発達脳 / 電気生理 / 過分極活性化陽イオン電流 / 電気生理学 / Patch-Clamp法 / Ih電流 / GABA受容体 / パッチクランプ / tonicGABA |
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| Outline of Final Research Achievements |
The use of volatile anesthetics is an exceedingly common practice. However, over the decade, volatile anesthetics induced neurotoxicity in pediatric populations has gained a certain notoriety based on animal studies demonstrating that these anesthetics may in neurotoxicity including neuro-apoptosis and long-term neurocognitive. And, volatile anesthetics have been reported to inhibit the hyperpolarization-activated cation current (Ih) that contributes to generation of synchronized oscillatory neural rhythms. The developmental change of Ih has been speculated to play a pivotal role during maturation. We examined the effect of volatile anesthetic sevoflurane on Ih in striatum. Our analyses showed that the change in Ih of cholinergic interneurons occurred in conjunction it with maturation.
The sevoflurane-induced inhibition of Ih in striatal cholinergic interneurons may lead to alternations of the acetylcholine-dopamine balance in the neural circuits during the early postnatal period.
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Report
(4 results)
Research Products
(3 results)
