| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
To investigate the effects of IL-1beta on synaptic plasticity, we examined long-term potentiation (LTP) electrophysiologically in different hippocampal regions in acute mouse brain slices. Our results demonstrated that IL-1beta exerted variable effects on LTP at different kinds of synapses, indicating that IL-1beta had synapse-specific effects on hippocampal synaptic plasticity.
Next, we investigated the effects of minocycline (MINO) on LTP in the hippocampus in a cecal ligation and puncture (CLP) mouse model. We have provided the evidence that MINO prevents impaired LTP related to sepsis-induced encephalopathy in the mouse hippocampus, and that mechanisms associated with IL-1 receptor activity may be involved.
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