| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The aim of this research is to investigate the mechanisms of chronic pain development by examining the above-mentioned relationships by voxel-based morphometry (VBM) in patients with chronic pain. First, we assessed neuropathic characteristics using the painDETECT questionnaire (PD-Q) in 12 chronic pain patients. Second, to assess the gray matter volume changes by VBM, we conducted magnetic resonance imaging (MRI) of the brain. We applied multiple regression analysis of these two assessment methods. There were significant positive correlations between PD-Q scores and the gray matter volume in the bilateral anterior cingulate cortex and, right posterior cingulate cortex, and right posterior insula. Our findings suggest that neuropathic characteristics strongly affect the brain regions related to perception and modulation of pain in patients with chronic pain and therefore contribute to the severity of chronic pain.
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