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Effects of protective one-lung ventilation on respiratory and renal outcomes in patients undergoing esophagectomy

Research Project

Project/Area Number 25462426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ishikawa Seiji  東京医科歯科大学, 医学部附属病院, 講師 (60282737)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords一側肺換気 / 保護的換気戦略 / 急性腎障害 / 食道切除術 / 食道癌 / バイオマーカー / 肺保護換気 / 術後合併症 / 保護的一側肺換気 / 術後肺合併症 / 急性腎傷害 / 炎症性サイトカイン
Outline of Final Research Achievements

We have investigated the effects of different one-lung ventilation (OLV) strategy on the outcome variables in patients undergoing esophagectomy. After randomization, 13 and 18 patients were allocated in conventional OLV group and protective OLV group, respectively. No outcome variables including mortality rate, duration of hospital stay, duration of intensive care unit stay, and need for reintubation was significantly different between the groups. No renal biomarkers was found to be different between the groups. The present study may suggest that the effects of protective OLV on the outcome variables are minimal in patients undergoing esophagectomy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Successful anesthesia management for 2-stage surgical procedure of a refractory tracheogastric tube fistula after esophagectomy.2016

    • Author(s)
      Ishibashi T, Ishikawa S, Suzuki A, et al.
    • Journal Title

      A A Case Rep

      Volume: 6 Issue: 4 Pages: 84-7

    • DOI

      10.1213/xaa.0000000000000257

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 開胸手術の呼吸管理を再考する. ~一側肺換気は必須か~2015

    • Author(s)
      石川晴士
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 35 Pages: 351-6

    • NAID

      130005094081

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 周術期急性腎傷害に関する最近の話題2015

    • Author(s)
      石川晴士
    • Journal Title

      臨床麻酔

      Volume: 39 Pages: 1095-103

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Acute kidney injury within 72 hours after lung transplantation: incidence and peroperative risk factors.2014

    • Author(s)
      Ishikawa S, Griesdale DE, Lohser J.
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: in press Issue: 4 Pages: 931-935

    • DOI

      10.1053/j.jvca.2013.08.013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 周術期腎障害と予防法2014

    • Author(s)
      石川晴士
    • Journal Title

      臨床麻酔第38巻臨時増刊号

      Volume: 38 Pages: 283-294

    • Related Report
      2013 Research-status Report
  • [Journal Article] About predictors of acute kidney injury after lung resection. Reply.2013

    • Author(s)
      Griesdale D, Ishikawa S, Lohser J.
    • Journal Title

      Anesth Analg

      Volume: 116 Issue: 2 Pages: 505-506

    • DOI

      10.1213/ane.0b013e3182776ea9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 麻酔科専門医が知っておきたい急性腎障害関連の基礎知識.2015

    • Author(s)
      石川晴士
    • Organizer
      日本臨床麻酔学会第35回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 肝臓切除術後のわずかな血清クレアチニン値の上昇と転帰との関係.2015

    • Author(s)
      東平哲之、石川晴士、塩田修玄、深川亜梨紗、槇田浩史
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県神戸市)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓切除術症例における術後急性腎傷害 (acute kidney injury: AKI) 発症のリスク因子に関する検討

    • Author(s)
      友澤亜梨紗、石川晴士、塩田修玄、Phantila Cholvisudhi、槇田浩史
    • Organizer
      (社)日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Perioperative risk factors of acute kidney injury after liver resection surgery under sevoflurane anesthesia.

    • Author(s)
      Shiota N, Ishikawa S, Tomozawa A, Cholvisudhi P, Makita K
    • Organizer
      Annual Meeting of American Society of ANesthesiologists
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Research-status Report
  • [Presentation] 開胸手術の呼吸管理を再考する~一側肺換気は必須か~

    • Author(s)
      石川晴士
    • Organizer
      日本臨床麻酔学会第33回大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] まれな疾患の麻酔 A to Z.2015

    • Author(s)
      石川晴士、羽深鎌一郎.
    • Total Pages
      2
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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