Biomarker profiles of perioperative acute lung injury

• Project/Area Number: 25462427
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Mamoru Yamamoto 東京医科歯科大学, 医学部附属病院, 助教 (90422477)
• Co-Investigator(Kenkyū-buntansha): 三高 千恵子 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20126254) ; 内田 篤治郎 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40262183)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: バイオマーカー / 急性肺傷害 / 周術期 / 心臓手術

Outline of Final Research Achievements

In this study, we measured serum levels of interleukin-8 and angiopoietin-II in (1) 80 patients undergoing elective cardiac surgery, and (2) 70 patients undergoing lung surgery. We showed that serum levels of angiopoietin-II elevated up to POD-1 whereas interleukin-8 levels peaked immediately after surgery in these two study cohorts. In the lung surgery study, the serum levels of these two biomarkers were significantly higher in patients undergoing pleurectomy/decortication, than those in patients undergoing lobectomy.

Research Products

• [Journal Article] Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction. (2016)
  • Author(s): Qi Y, Uchida T, Yamamoto M, Yamamoto Y, Kido K, Ito H, Ohno N, Asahara M, Yamada Y, Yamaguchi O, Mitaka C, Tomita M, Makita K.
  • Journal Title: Anesthesiol Res Pract Volume: 2016 Pages: 2794364-2794364
  • DOI: 10.1155/2016/2794364
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Soluble Isoform of the Receptor for Advanced Glycation End Products as a Biomarker for Postoperative Respiratory Failure after Cardiac Surgery (2013)
  • Author(s): Uchida T, Ohno N, Asahara M, Yamada Y, Yamaguchi O, Tomita M, Makita K
  • Journal Title: Plos One Volume: 8 Issue: 7 Pages: e70200-e70200
  • DOI: 10.1371/journal.pone.0070200
  • Peer Reviewed
• [Presentation] Perioperative Elevation in Cell Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction: A Multicenter Observational Study (2015)
  • Author(s): 5.Yamamoto Y, Uchida T, Ito H, Kido K, Yamamoto Y, Yamada Y, Ohno N, Asahara M, Yamaguchi O, Makita K.
  • Organizer: Anesthesiology 2015.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-10-24
  • Int'l Joint Research
• [Presentation] 全身麻酔中の換気設定を見直す：手術室における人工呼吸器の設定について（分離肺換気症例を除く）：術後急性肺合併症の予防と肺保護的換気法. (2015)
  • Author(s): 内田篤治郎
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2015-05-28
• [Presentation] Serum Angiopoietin-2 as a Biomarker for Postoperative Respiratory Failure After Cardiac Surgery.
  • Author(s): 11. Yamamoto H, Uchida T, Ito H, Ohno N, Asahara M, Yamada Y, Yamaguchi O, Makita K
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: SanFrancisco, USA